Literature DB >> 11072124

Agouti-related protein in the hypothalamic paraventricular nucleus: effect on feeding.

M M Wirth1, S Q Giraudo.   

Abstract

Agouti-related protein (Agrp) is an endogenous melanocortin-4 receptor antagonist implicated in the regulation of food intake. Effects of Agrp on feeding under varying conditions were investigated. Agrp (10 to 100 pmol) was injected into the hypothalamic paraventricular nucleus of satiated (a.m. and p.m. injections) and food-deprived rats, or was co-administered with 117 pmol Neuropeptide Y (NPY). Agrp significantly stimulated light-phase feeding by 24 h post-injection. However, Agrp stimulated dark-phase and deprivation-induced feeding by 4 and 2 h, respectively. Animals receiving NPY and Agrp consumed more than animals receiving either peptide alone, the effect remaining by 24 h.

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Year:  2000        PMID： 11072124     DOI： 10.1016/s0196-9781(00)00280-1

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  15 in total

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4.  Altered feeding and body weight following melanocortin administration to the ventral tegmental area in adult rats.

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Review 5.  Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use.

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Review 6.  The MC4 receptor and control of appetite.

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Authors:  Zoe M Koerperich; Mark D Ericson; Katie T Freeman; Robert C Speth; Irina D Pogozheva; Henry I Mosberg; Carrie Haskell-Luevano
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8.  Inhibition of ghrelin O-acyltransferase attenuates food deprivation-induced increases in ingestive behavior.

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9.  Contribution of the transmembrane domain 6 of melanocortin-4 receptor to peptide [Pro5, DNal (2')8]-gamma-MSH selectivity.

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10.  Coordinated changes in energy intake and expenditure following hypothalamic administration of neuropeptides involved in energy balance.

Authors:  N M Semjonous; K L Smith; J R C Parkinson; D J L Gunner; Y-L Liu; K G Murphy; M A Ghatei; S R Bloom; C J Small
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