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Literature DB >> 11071372

Acute multiple sclerosis characterized by extensive mononuclear phagocyte infiltration.

D C Shields¹, N G Avgeropoulos, N L Banik, W R Tyor.

Abstract

In this study, we examine the clinical, neuroradiological, and immunohistochemical findings of a 51 year old white female who died 27 months after onset of acute multiple sclerosis despite treatment with interferon-beta, azathioprine, corticosteroids, and cyclophosphamide. Immunohistochemical studies revealed extensive gliosis and mononuclear phagocyte infiltration with corresponding upregulation of proinflammatory cytokines (eg. IFN-alpha, TNF-alpha). The significance of immunohistochemical findings with respect to clinical presentation is discussed.

Entities: Chemical Disease Gene

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Year: 2000 PMID： 11071372 DOI： 10.1023/a:1007636427861

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

14 in total

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2. Tumour necrosis factor alpha is expressed in refractory skin lesions from patients with subacute cutaneous lupus erythematosus.

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