Literature DB >> 11070563

Pregnancy outcome in women with type 2 diabetes mellitus needs to be addressed.

P Brydon1, T Smith, M Proffitt, H Gee, R Holder, F Dunne.   

Abstract

Maternal diabetes mellitus (types 1 and 2) is the most chronic prevalent medical condition affecting the pregnant population and is associated with a less satisfactory pregnancy outcome for both mother and infant when compared with the non-diabetic population. Most reports have focused on women with type 1 disease, type 2 disease being perceived as a less serious condition. However, type 2 disease is far more common (and is increasing) in some areas of the UK, especially where there is a high proportion of women from the Indian subcontinent. This paper shows that pregnancy complicated by type 2 diabetes mellitus is a high-risk state, with miscarriage and congenital malformations almost twice that seen in type 1 disease. These adverse outcomes are contributed to by poor attendance for pre-pregnancy care, later booking for antenatal clinic and poor glycaemic control at booking. Offspring of pregnancies complicated by type 2 diabetes are more likely to be delivered before 37 weeks gestation and be large in size for gestational age. We must dispel the myth, in women of childbearing age and in their healthcare providers, that diabetes treated with diet and/or tablets (type 2) is a less serious problem than type 1 disease.

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Year:  2000        PMID: 11070563

Source DB:  PubMed          Journal:  Int J Clin Pract        ISSN: 1368-5031            Impact factor:   2.503


  17 in total

Review 1.  Congenital malformations in offspring of diabetic mothers--animal and human studies.

Authors:  Ulf J Eriksson; Jonas Cederberg; Parri Wentzel
Journal:  Rev Endocr Metab Disord       Date:  2003-03       Impact factor: 6.514

Review 2.  Diabetic embryopathy: a role for the epigenome?

Authors:  J Michael Salbaum; Claudia Kappen
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2011-05-02

Review 3.  Optimal Obstetric Management for Women with Diabetes: the Benefits and Costs of Fetal Surveillance.

Authors:  Ukachi N Emeruwa; Chloe Zera
Journal:  Curr Diab Rep       Date:  2018-09-07       Impact factor: 4.810

4.  Augmented dilation to nitric oxide in uterine arteries from rats with type 2 diabetes: implications for vascular adaptations to pregnancy.

Authors:  Styliani Goulopoulou; Johanna L Hannan; Takayuki Matsumoto; Adviye Ergul; R Clinton Webb
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-12-13       Impact factor: 4.733

5.  Perinatal mortality and congenital anomalies in babies of women with type 1 or type 2 diabetes in England, Wales, and Northern Ireland: population based study.

Authors:  Mary C M Macintosh; Kate M Fleming; Jaron A Bailey; Pat Doyle; Jo Modder; Dominique Acolet; Shona Golightly; Alison Miller
Journal:  BMJ       Date:  2006-06-16

6.  Responses of the embryonic epigenome to maternal diabetes.

Authors:  J Michael Salbaum; Claudia Kappen
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2012-07-11

7.  Maternal diabetes in the rat impairs the formation of neural-crest derived cranial nerve ganglia in the offspring.

Authors:  J Cederberg; J J Picard; U J Eriksson
Journal:  Diabetologia       Date:  2003-06-27       Impact factor: 10.122

Review 8.  Development of early-onset type 2 diabetes in the young: implications for child bearing.

Authors:  Carol J Homko; E Albert Reece
Journal:  Curr Diab Rep       Date:  2003-08       Impact factor: 4.810

9.  Evaluation of neonatally-induced mild diabetes in rats: Maternal and fetal repercussions.

Authors:  Isabela L Iessi; Aline Bueno; Yuri K Sinzato; Kristin N Taylor; Marilza Vc Rudge; Débora C Damasceno
Journal:  Diabetol Metab Syndr       Date:  2010-06-08       Impact factor: 3.320

10.  Gestational diabetes mellitus: a qualitative study of lived experiences of South Asian immigrant women and perspectives of their health care providers in Melbourne, Australia.

Authors:  Mridula Bandyopadhyay
Journal:  BMC Pregnancy Childbirth       Date:  2021-07-09       Impact factor: 3.007

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