| Literature DB >> 11069309 |
G Sachs1, J M Shin, K Munson, O Vagin, N Lambrecht, D R Scott, D L Weeks, K Melchers.
Abstract
This review focuses on the gastric acid pump as a therapeutic target for the control of acid secretion in peptic ulcer and gastro-oesophageal reflux disease. The mechanism of the proton pump inhibitors is discussed as well as their clinical use. The biology of Helicobacter pylori as a gastric denizen is then discussed, with special regard to its mechanisms of acid resistance. Here the properties of the products of the urease gene clusters, ureA, B and ureI, E, F, G and H are explored in order to explain the unique location of this pathogen. The dominant requirement for acid resistance is the presence of a proton gated urea transporter, UreI, which increases access of gastric juice urea to the intrabacterial urease 300-fold. This enables rapid and continuous buffering of the bacterial periplasm to approximately pH 6.0, allowing acid resistance and growth at acidic pH in the presence of 1 mM urea. A hypothesis for the basis of combination therapy for eradication is also presented.Entities:
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Year: 2000 PMID： 11069309 DOI： 10.1046/j.1365-2036.2000.00837.x
Source DB: PubMed Journal: Aliment Pharmacol Ther ISSN： 0269-2813 Impact factor: 8.171