D E Vaillancourt1, K M Newell. 1. Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA. dev107@psu.edu
Abstract
OBJECTIVE: The study examines the time and frequency structure of Parkinson's disease tremor in patients that exhibit no clinical signs of tremor. METHODS: Eight mild to moderate Parkinson's disease and 8 matched control subjects maintained their limb in a constant position (30 s) under a postural finger, postural hand and resting tremor condition. Finger acceleration from the middle phalange, electromyographic (EMG) activity from extensor digitorum communis and flexor digitorum superficialis (FDS) were recorded. RESULTS: The data confirmed that there were no differences in the amount of limb motion and the modal frequency was around 9 Hz for each subject group. The time-dependent organization of tremor was more regular (lower approximate entropy [ApEn]) in Parkinson's disease. Both time and frequency analyses between the acceleration and extensor EMG signals demonstrate a reduction in the 20-25 Hz tremor component and an increase in the 8-12 Hz region of tremor. CONCLUSIONS: The results are discussed in relation to the proposal that increased regularity results from an increase in motor unit synchronization at 8-12 Hz and a reduction in the amplitude of the 20-25 Hz tremor component. The time and frequency structure of tremor may be useful in assessing individuals with Parkinson's disease.
OBJECTIVE: The study examines the time and frequency structure of Parkinson's diseasetremor in patients that exhibit no clinical signs of tremor. METHODS: Eight mild to moderate Parkinson's disease and 8 matched control subjects maintained their limb in a constant position (30 s) under a postural finger, postural hand and resting tremor condition. Finger acceleration from the middle phalange, electromyographic (EMG) activity from extensor digitorum communis and flexor digitorum superficialis (FDS) were recorded. RESULTS: The data confirmed that there were no differences in the amount of limb motion and the modal frequency was around 9 Hz for each subject group. The time-dependent organization of tremor was more regular (lower approximate entropy [ApEn]) in Parkinson's disease. Both time and frequency analyses between the acceleration and extensor EMG signals demonstrate a reduction in the 20-25 Hz tremor component and an increase in the 8-12 Hz region of tremor. CONCLUSIONS: The results are discussed in relation to the proposal that increased regularity results from an increase in motor unit synchronization at 8-12 Hz and a reduction in the amplitude of the 20-25 Hz tremor component. The time and frequency structure of tremor may be useful in assessing individuals with Parkinson's disease.
Authors: Jun Jiang; Kory J Golchert; Carolyn N Kingsley; William D Brubaker; Rachel W Martin; Shaul Mukamel Journal: J Phys Chem B Date: 2013-11-12 Impact factor: 2.991
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