Literature DB >> 1106748

Demonstration of immunoglobulin containing deposits in glomerular basement membrane in experimental chronic serum sickness using horseradish peroxidase labelled antiserum.

D R Davies, A E Clark.   

Abstract

Horseradish peroxidase (HRP) labelled antibodies were used in rabbit glomerulonephritis to obtain localization of immunoglobulins in the glomerulus at a light and electron microscope level. Better localization of deposits was obtained with peroxidase labelled antiserum than with immunofluorescence at the light microscope level. Ultrastructurally, immunoglobulin localization was seen to correspond to the electron dense deposits demonstrated in and on the glomerular basement membrane by conventional microscopy.

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Year:  1975        PMID： 1106748      PMCID： PMC2072712     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  4 in total

1.  Nephrotoxic serum nephritis in the rat: ultrastructural localization of nephrotoxic rabbit antibodies using peroxidase-labeled conjugates.

Authors:  P Druet; J Bariety; B Bellon; F Laliberte
Journal:  Lab Invest       Date:  1972-08       Impact factor: 5.662

2.  Immunohistochemistry of glomerulonephritis using horseradish peroxidase and fluorescein-labeled antibody: a comparison of two technics.

Authors:  F R Davey; G J Busch
Journal:  Am J Clin Pathol       Date:  1970-04       Impact factor: 2.493

3.  The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.

Authors:  R C Graham; M J Karnovsky
Journal:  J Histochem Cytochem       Date:  1966-04       Impact factor: 2.479

4.  Electron microscopic studies of experimental nephritis with ferritin-conjugated antibody. Localization of antigen-antibody complexes in rabbit glomeruli following repeated injections of bovine serum albumin.

Authors:  G A ANDRES; B C SEEGAL; K C HSU; M S ROTHENBERG; M L CHAPEAU
Journal:  J Exp Med       Date:  1963-04-01       Impact factor: 14.307
  4 in total
  5 in total

1.  Immunoperoxidase autopsy study of crescentic glomerulonephritis with extracapillary proliferation.

Authors:  T Tóth
Journal:  Int Urol Nephrol       Date:  1989       Impact factor: 2.370

2.  Distribution of annionic sites in glomerular basement membranes: their possible role in filtration and attachment.

Authors:  J P Caulfield; M G Farquhar
Journal:  Proc Natl Acad Sci U S A       Date:  1976-05       Impact factor: 11.205

3.  Light and electron microscopic demonstration of extracellular immunoglobulin deposition in renal tissue.

Authors:  M D al-Nawab; D R Davies
Journal:  J Clin Pathol       Date:  1989-10       Impact factor: 3.411

4.  Demonstration of immunoproteins in araldite-embedded tissues.

Authors:  J Giddings; R L Griffin; A G Maciver
Journal:  J Clin Pathol       Date:  1982-01       Impact factor: 3.411

5.  Fixation and embedding variables in the immuno-electron microscopic study of rat Heymann nephritis.

Authors:  I Rantala; H Helin; M Helin; V Kotti; A Pasternack
Journal:  Histochemistry       Date:  1980
  5 in total

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