Literature DB >> 11065139

Expression of metallothionein-III mRNA and its regulation by levodopa in the basal ganglia of hemi-parkinsonian rats.

I Miyazaki1, C A Sogawa, M Asanuma, Y Higashi, K I Tanaka, T Nakanishi, N Ogawa.   

Abstract

In the brain, metallothionein (MT)-III exhibits a free radical scavenging activity. Here we examined the expression of MT-III mRNA in the basal ganglia of 6-hydroxydopamine (6-OHDA)-lesioned hemi-parkinsonian rats and its regulation by levodopa. The level of MT-III mRNA was significantly decreased in the striatum of 6-OHDA-lesioned side. Levodopa treatment significantly increased the expression of striatal MT-III mRNA in the non-lesioned side, but showed no significant effect in the 6-OHDA-lesioned side. These results suggest that the regulation of MT-III mRNA may be related to the progressive degeneration in parkinsonism.

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Year:  2000        PMID： 11065139     DOI： 10.1016/s0304-3940(00)01488-9

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  7 in total

1.  Membrane insertion exacerbates the α-Synuclein-Cu(II) dopamine oxidase activity: Metallothionein-3 targets and silences all α-synuclein-Cu(II) complexes.

Authors:  Jenifer S Calvo; Neha V Mulpuri; Alex Dao; Nabeeha K Qazi; Gabriele Meloni
Journal:  Free Radic Biol Med       Date:  2020-07-23       Impact factor: 7.376

Review 2.  Thiol-redox signaling, dopaminergic cell death, and Parkinson's disease.

Authors:  Aracely Garcia-Garcia; Laura Zavala-Flores; Humberto Rodriguez-Rocha; Rodrigo Franco
Journal:  Antioxid Redox Signal       Date:  2012-05-03       Impact factor: 8.401

Review 3.  Metallothionein in Brain Disorders.

Authors:  Daniel Juárez-Rebollar; Camilo Rios; Concepción Nava-Ruíz; Marisela Méndez-Armenta
Journal:  Oxid Med Cell Longev       Date:  2017-09-20       Impact factor: 6.543

Review 4.  Zinc in Cognitive Impairment and Aging.

Authors:  Ruize Sun; Jue Wang; Juan Feng; Bin Cao
Journal:  Biomolecules       Date:  2022-07-18

5.  Lack of dopaminergic inputs elongates the primary cilia of striatal neurons.

Authors:  Ko Miyoshi; Kyosuke Kasahara; Shinki Murakami; Mika Takeshima; Natsuko Kumamoto; Asako Sato; Ikuko Miyazaki; Shinsuke Matsuzaki; Toshikuni Sasaoka; Taiichi Katayama; Masato Asanuma
Journal:  PLoS One       Date:  2014-05-15       Impact factor: 3.240

6.  Prolongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans.

Authors:  Dagmar Pretsch; Judith Maria Rollinger; Axel Schmid; Miroslav Genov; Teresa Wöhrer; Liselotte Krenn; Mark Moloney; Ameya Kasture; Thomas Hummel; Alexander Pretsch
Journal:  Sci Rep       Date:  2020-07-16       Impact factor: 4.379

Review 7.  Metallothionein-3 as a multifunctional player in the control of cellular processes and diseases.

Authors:  Jae-Young Koh; Sook-Jeong Lee
Journal:  Mol Brain       Date:  2020-08-25       Impact factor: 4.041
  7 in total

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