OBJECTIVE: Insulin-like growth factor-1 (IGF-1) and its principal binding protein-3 (IGFBP-3) are central in the mediation of the effect of growth hormone, and the IGF system has been reported to play a role in the pathogenesis of childhood leukemia. METHODS: To further evaluate the hypothesis connecting the IGF system to this disease, we have examined whether IGF-1 and IGFBP-3 are associated with the two main endogenous risk factors for childhood leukemia, namely gender and birth weight, since boys and heavier newborns are known to be at higher risk. IGF-1 and IGFBP-3 were measured under code in the serum of 118 apparently healthy children aged 0-14 years and the values of each of these components were regressed on age, gender and birth weight. Insulin-like growth factor-2 (IGF-2), as a dependent variable, and anemia during the corresponding pregnancy, as a predictor variable, were also evaluated for exploratory purposes. RESULTS: In the total data set, IGF-1 was positively associated with birth weight (p = 0.0001), whereas girls had higher levels of IGFBP-3 (p = 0.01). CONCLUSIONS: It appears that the associations of measured components of the IGF system with the examined risk factors for childhood leukemia are largely compatible with those that would have been expected, if this system played a role in the pathogenesis of childhood leukemia.
OBJECTIVE:Insulin-like growth factor-1 (IGF-1) and its principal binding protein-3 (IGFBP-3) are central in the mediation of the effect of growth hormone, and the IGF system has been reported to play a role in the pathogenesis of childhood leukemia. METHODS: To further evaluate the hypothesis connecting the IGF system to this disease, we have examined whether IGF-1 and IGFBP-3 are associated with the two main endogenous risk factors for childhood leukemia, namely gender and birth weight, since boys and heavier newborns are known to be at higher risk. IGF-1 and IGFBP-3 were measured under code in the serum of 118 apparently healthy children aged 0-14 years and the values of each of these components were regressed on age, gender and birth weight. Insulin-like growth factor-2 (IGF-2), as a dependent variable, and anemia during the corresponding pregnancy, as a predictor variable, were also evaluated for exploratory purposes. RESULTS: In the total data set, IGF-1 was positively associated with birth weight (p = 0.0001), whereas girls had higher levels of IGFBP-3 (p = 0.01). CONCLUSIONS: It appears that the associations of measured components of the IGF system with the examined risk factors for childhood leukemia are largely compatible with those that would have been expected, if this system played a role in the pathogenesis of childhood leukemia.
Authors: Elizabeth Milne; Kathryn R Greenop; Catherine Metayer; Joachim Schüz; Eleni Petridou; Maria S Pombo-de-Oliveira; Claire Infante-Rivard; Eve Roman; John D Dockerty; Logan G Spector; Sérgio Koifman; Laurent Orsi; Jérémie Rudant; Nick Dessypris; Jill Simpson; Tracy Lightfoot; Peter Kaatsch; Margarita Baka; Alessandra Faro; Bruce K Armstrong; Jacqueline Clavel; Patricia A Buffler Journal: Int J Cancer Date: 2013-08-01 Impact factor: 7.396
Authors: Elva Jiménez-Hernández; Arturo Fajardo-Gutiérrez; Juan Carlos Núñez-Enriquez; Jorge Alfonso Martín-Trejo; Laura Eugenia Espinoza-Hernández; Janet Flores-Lujano; José Arellano-Galindo; Aurora Medina-Sanson; Rogelio Paredes-Aguilera; Laura Elizabeth Merino-Pasaye; Martha Margarita Velázquez-Aviña; José Refugio Torres-Nava; Rosa Martha Espinosa-Elizondo; Raquel Amador-Sánchez; Juan José Dosta-Herrera; Javier Anastacio Mondragón-García; Heriberto Valdés-Guzmán; Laura Mejía-Pérez; Gilberto Espinoza-Anrubio; María Minerva Paz-Bribiesca; Perla Salcedo-Lozada; Rodolfo Ángel Landa-García; Rosario Ramírez-Colorado; Luis Hernández-Mora; María Luisa Pérez-Saldivar; Marlene Santamaría-Ascencio; Anselmo López-Loyola; Arturo Hermilo Godoy-Esquivel; Luis Ramiro García-López; Alison Ireri Anguiano-Ávalos; Karina Mora-Rico; Alejandro Castañeda-Echevarría; Roberto Rodríguez-Jiménez; José Alberto Cibrian-Cruz; Karina Anastacia Solís-Labastida; Rocío Cárdenas-Cardos; Armando Martínez-Avalos; Luz Victoria Flores-Villegas; José Gabriel Peñaloza-González; Ana Itamar González-Ávila; Martha Beatriz Altamirano-García; Norma López-Santiago; Martin Sánchez-Ruiz; Roberto Rivera-Luna; Luis Rodolfo Rodríguez-Villalobos; Francisco Hernández-Pérez; Jaime Ángel Olvera-Durán; Luis Rey García-Cortés; Minerva Mata-Rocha; Omar Alejandro Sepúlveda-Robles; Cesar Raúl González-Bonilla; Vilma Carolina Bekker-Méndez; Silvia Jiménez-Morales; Haydee Rosas-Vargas; Juan Manuel Mejía-Aranguré Journal: Cancer Med Date: 2018-03-13 Impact factor: 4.452
Authors: Zuelma A Contreras; Beate Ritz; Jasveer Virk; Myles Cockburn; Julia E Heck Journal: Cancer Causes Control Date: 2016-09-09 Impact factor: 2.532