Literature DB >> 11063935

Genes involved in senescence and immortalization.

A S Lundberg1, W C Hahn, P Gupta, R A Weinberg.   

Abstract

Senescence is now understood to be the final phenotypic state adopted by a cell in response to several distinct cell physiological processes, including proliferation, oncogene activation and oxygen free radical toxicity. The role of telomere maintenance in immortalization and the roles of p16(INK4A), p19(ARF), p53 and other genes in senescence are being further elucidated. Significant progress continues to be made in our understanding of cellular senescence and immortalization.

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Year:  2000        PMID： 11063935     DOI： 10.1016/s0955-0674(00)00155-1

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  95 in total

1.  Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci.

Authors:  Hong Zhang; Kuang-Hung Pan; Stanley N Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-07       Impact factor: 11.205

2.  Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform.

Authors:  Liu Cao; Wenmei Li; Sangsoo Kim; Steven G Brodie; Chu-Xia Deng
Journal:  Genes Dev       Date:  2003-01-15       Impact factor: 11.361

3.  Bcl-2 activates a programme of premature senescence in human carcinoma cells.

Authors:  Elvira Crescenzi; Giuseppe Palumbo; Hugh J M Brady
Journal:  Biochem J       Date:  2003-10-15       Impact factor: 3.857

4.  Degradation of p53, not telomerase activation, by E6 is required for bypass of crisis and immortalization by human papillomavirus type 16 E6/E7.

Authors:  H R McMurray; D J McCance
Journal:  J Virol       Date:  2004-06       Impact factor: 5.103

5.  Cellular senescence requires CDK5 repression of Rac1 activity.

Authors:  Kamilah Alexander; Hai-Su Yang; Philip W Hinds
Journal:  Mol Cell Biol       Date:  2004-04       Impact factor: 4.272

Review 6.  Pathways of oncogene-induced senescence in human melanocytic cells.

Authors:  Rajat Bansal; Mikhail A Nikiforov
Journal:  Cell Cycle       Date:  2010-07-03       Impact factor: 4.534

7.  c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression.

Authors:  Hui-Yi Kua; Huijuan Liu; Wai Fook Leong; Lili Li; Deyong Jia; Gang Ma; Yuanyu Hu; Xueying Wang; Jenny F L Chau; Ye-Guang Chen; Yuji Mishina; Sharon Boast; James Yeh; Li Xia; Guo-Qiang Chen; Lin He; Stephen P Goff; Baojie Li
Journal:  Nat Cell Biol       Date:  2012-06-24       Impact factor: 28.824

Review 8.  From the raw bar to the bench: Bivalves as models for human health.

Authors:  José A Fernández Robledo; Raghavendra Yadavalli; Bassem Allam; Emmanuelle Pales Espinosa; Marco Gerdol; Samuele Greco; Rebecca J Stevick; Marta Gómez-Chiarri; Ying Zhang; Cynthia A Heil; Adrienne N Tracy; David Bishop-Bailey; Michael J Metzger
Journal:  Dev Comp Immunol       Date:  2018-11-29       Impact factor: 3.636

9.  Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.

Authors:  Lei Wang; Linda Yang; Marcella Debidda; David Witte; Yi Zheng
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-16       Impact factor: 11.205

10.  5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation.

Authors:  Alfonso Catalano; Sabrina Rodilossi; Paola Caprari; Vincenzo Coppola; Antonio Procopio
Journal:  EMBO J       Date:  2004-12-16       Impact factor: 11.598
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