| Literature DB >> 11063292 |
S Fukaya1, H Oshima, K Kato, Y Komatsu, H Matsumura, K Ishii, H Miyama, T Nagai, I Tanaka, A Mizutani, M Katayama, S Yoshida, K Torikai.
Abstract
The objective of this study was to determine the role of serum KL-6 levels as a marker for the activity of interstitial pneumonia in patients with connective tissue diseases. The serum concentrations of KL-6, a glycoprotein produced mainly by pulmonary type II epithelial cells, were measured in 21 patients with connective tissue disease. The activity of interstitial pneumonia was compared with the associated serum KL-6 concentrations. Serum KL-6 concentrations in patients with interstitial pneumonia were significantly higher than those in the controls. Among patients with active interstitial pneumonia, serum KL-6 concentrations following the treatment (after improvement) were significantly lower than the pretreatment values. The extent of the pulmonary fibrosis correlated positively with the serum KL-6 concentrations during the inactive phase of the interstitial pneumonia. These results suggest that sequential measurement of serum KL-6 levels is a new and useful means for the evaluation of interstitial pneumonia in patients with connective tissue diseases.Entities:
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Year: 2000 PMID： 11063292 DOI： 10.1007/s002960000064
Source DB: PubMed Journal: Rheumatol Int ISSN： 0172-8172 Impact factor: 2.631