| Literature DB >> 11062560 |
C Frazão1, G Silva, C M Gomes, P Matias, R Coelho, L Sieker, S Macedo, M Y Liu, S Oliveira, M Teixeira, A V Xavier, C Rodrigues-Pousada, M A Carrondo, J Le Gall.
Abstract
Desulfovibrio gigas is a strict anaerobe that contains a well-characterized metabolic pathway that enables it to survive transient contacts with oxygen. The terminal enzyme in this pathway, rubredoxin:oxygen oxidoreductase (ROO) reduces oxygen to water in a direct and safe way. The 2.5 A resolution crystal structure of ROO shows that each monomer of this homodimeric enzyme consists of a novel combination of two domains, a flavodoxin-like domain and a Zn-beta-lactamase-like domain that contains a di-iron center for dioxygen reduction. This is the first structure of a member of a superfamily of enzymes widespread in strict and facultative anaerobes, indicating its broad physiological significance.Entities:
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Year: 2000 PMID： 11062560 DOI： 10.1038/80961
Source DB: PubMed Journal: Nat Struct Biol ISSN： 1072-8368