| Literature DB >> 11062467 |
J J Jacobs1, P Keblusek, E Robanus-Maandag, P Kristel, M Lingbeek, P M Nederlof, T van Welsem, M J van de Vijver, E Y Koh, G Q Daley, M van Lohuizen.
Abstract
To identify new immortalizing genes with potential roles in tumorigenesis, we performed a genetic screen aimed to bypass the rapid and tight senescence arrest of primary fibroblasts deficient for the oncogene Bmi1. We identified the T-box member TBX2 as a potent immortalizing gene that acts by downregulating Cdkn2a (p19(ARF)). TBX2 represses the Cdkn2a (p19(ARF)) promoter and attenuates E2F1, Myc or HRAS-mediated induction of Cdkn2a (p19(ARF)). We found TBX2 to be amplified in a subset of primary human breast cancers, indicating that it might contribute to breast cancer development.Entities:
Mesh：
Substances：
Year: 2000 PMID： 11062467 DOI： 10.1038/81583
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330