Literature DB >> 11062206

Metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France.

V Lemée1, I Zaharia, G Nevez, M Rabodonirina, P Brasseur, J J Ballet, L Favennec.   

Abstract

The metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France was determined using a neonatal mouse model and compared with the outcome in patients after standard metronidazole therapy (0.75 g/day for 5 days). All isolates found to be clinically resistant to metronidazole (4/11) exhibited an ID50 > 120 mg/kg in the mouse model. This therefore appears to be a suitable animal model in which to explore drug failures in human giardiasis.

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Year:  2000        PMID： 11062206     DOI： 10.1093/jac/46.5.819

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  43 in total

1.  A new-generation 5-nitroimidazole can induce highly metronidazole-resistant Giardia lamblia in vitro.

Authors:  Linda A Dunn; Anita G Burgess; Kenia G Krauer; Lars Eckmann; Patrice Vanelle; Maxime D Crozet; Frances D Gillin; Peter Upcroft; Jacqueline A Upcroft
Journal:  Int J Antimicrob Agents       Date:  2010-04-24       Impact factor: 5.283

2.  Drug susceptibility testing of anaerobic protozoa.

Authors:  J A Upcroft; P Upcroft
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

3.  Susceptibility of Giardia lamblia to Hovenia dulcis extracts.

Authors:  A P R Gadelha; F Vidal; T M Castro; C S Lopes; N Albarello; M G P Coelho; S F L Figueiredo; L H Monteiro-Leal
Journal:  Parasitol Res       Date:  2005-09-07       Impact factor: 2.289

4.  The in vitro anti-giardial activity of extracts from plants that are used for self-medication by AIDS patients in southern Thailand.

Authors:  N Sawangjaroen; S Subhadhirasakul; S Phongpaichit; C Siripanth; K Jamjaroen; K Sawangjaroen
Journal:  Parasitol Res       Date:  2004-11-18       Impact factor: 2.289

5.  In vitro effects of Crotalus durissus terrificus and Bothrops jararaca venoms on Giardia duodenalis trophozoites.

Authors:  Lina Shinohara; Stella Fellipe de Freitas; Reinaldo José da Silva; Semíramis Guimarães
Journal:  Parasitol Res       Date:  2005-12-24       Impact factor: 2.289

6.  Discovery of novel antigiardiasis drug candidates.

Authors:  Liudmila Kulakova; Andrey Galkin; Catherine Z Chen; Noel Southall; Juan J Marugan; Wei Zheng; Osnat Herzberg
Journal:  Antimicrob Agents Chemother       Date:  2014-09-29       Impact factor: 5.191

Review 7.  Understanding drug resistance in human intestinal protozoa.

Authors:  Hend Aly El-Taweel
Journal:  Parasitol Res       Date:  2015-03-19       Impact factor: 2.289

8.  Structural basis for inactivation of Giardia lamblia carbamate kinase by disulfiram.

Authors:  Andrey Galkin; Liudmila Kulakova; Kap Lim; Catherine Z Chen; Wei Zheng; Illarion V Turko; Osnat Herzberg
Journal:  J Biol Chem       Date:  2014-02-20       Impact factor: 5.157

9.  A meta-analysis of the effectiveness of albendazole compared with metronidazole as treatments for infections with Giardia duodenalis.

Authors:  Shahram Solaymani-Mohammadi; Jeanine M Genkinger; Christopher A Loffredo; Steven M Singer
Journal:  PLoS Negl Trop Dis       Date:  2010-05-11

10.  Divergent Transcriptional Responses to Physiological and Xenobiotic Stress in Giardia duodenalis.

Authors:  Brendan R E Ansell; Malcolm J McConville; Louise Baker; Pasi K Korhonen; Samantha J Emery; Staffan G Svärd; Robin B Gasser; Aaron R Jex
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191
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