Literature DB >> 11061271

Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195.

S Pappata1, M Levasseur, R N Gunn, R Myers, C Crouzel, A Syrota, T Jones, G W Kreutzberg, R B Banati.   

Abstract

Using quantitative PET, the authors studied the binding of [11C]PK11195, a marker of activated microglia, in the thalamus of patients with chronic middle cerebral artery infarcts. All patients showed increased [11C]PK11195 binding in the ipsilateral thalamus, indicating the activation of microglia in degenerating projection areas remote from the primary lesion. A persistent increase in [11C]PK11195 binding suggests active, long-term thalamic microstructural changes after corticothalamic connection damage.

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Year:  2000        PMID： 11061271     DOI： 10.1212/wnl.55.7.1052

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


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