| Literature DB >> 11060452 |
R Shamsadin1, I M Adham, G von Beust, W Engel.
Abstract
The pelota gene of Drosophila melanogaster encodes a protein that was found to be included in cell cycle regulation. Mutations were found to result in spermatogenic arrest, female sterility and disturbances in the patterning of the eye. Here we describe the cloning of the human pelota cDNA (PELO) that encodes a 385-amino-acid protein. Southern blot and fluorescence in situ hybridization analyses revealed that PELO is present as a single copy gene in the human genome and is localized on chromosome 5q11.2. Northern blot analysis revealed the presence of a 1.6-kb transcript in all tissues studied and an additional 2.0-kb transcript in testis. Copyright 2000 S. Karger AG, Basel.Entities:
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Year: 2000 PMID: 11060452 DOI: 10.1159/000015667
Source DB: PubMed Journal: Cytogenet Cell Genet ISSN: 0301-0171