BACKGROUND: It is unclear whether outcome in schizoaffective disorders is more similar to schizophrenia or affective disorders. AIMS: To provide longitudinal data on clinical course and outcome in schizoaffective disorders versus schizophrenia and affective disorders, and determine whether mood-incongruent psychotic symptoms have negative prognostic implications. METHOD: A total of 210 patients with schizoaffective disorders, schizophrenia, bipolar manic disorders and depression were assessed at hospitalisation and then followed up four times over 10 years. RESULTS: At all four follow-ups, fewer patients with schizoaffective disorders than with schizophrenia showed uniformly poor outcome. Patients with mood-incongruent psychotic symptoms during index hospitalisation showed significantly poorer subsequent outcome (P < 0.05). CONCLUSIONS: Schizoaffective outcome was better than schizophrenic outcome and poorer than outcome for psychotic affective disorders. Mood-incongruent psychotic symptoms have negative prognostic implications. The results could fit a symptom dimension view of schizoaffective course.
BACKGROUND: It is unclear whether outcome in schizoaffective disorders is more similar to schizophrenia or affective disorders. AIMS: To provide longitudinal data on clinical course and outcome in schizoaffective disorders versus schizophrenia and affective disorders, and determine whether mood-incongruent psychotic symptoms have negative prognostic implications. METHOD: A total of 210 patients with schizoaffective disorders, schizophrenia, bipolar manic disorders and depression were assessed at hospitalisation and then followed up four times over 10 years. RESULTS: At all four follow-ups, fewer patients with schizoaffective disorders than with schizophrenia showed uniformly poor outcome. Patients with mood-incongruent psychotic symptoms during index hospitalisation showed significantly poorer subsequent outcome (P < 0.05). CONCLUSIONS: Schizoaffective outcome was better than schizophrenic outcome and poorer than outcome for psychotic affective disorders. Mood-incongruent psychotic symptoms have negative prognostic implications. The results could fit a symptom dimension view of schizoaffective course.
Authors: Ángel Del Rey-Mejías; David Fraguas; Covadonga M Díaz-Caneja; Laura Pina-Camacho; Josefina Castro-Fornieles; Inmaculada Baeza; Ana Espliego; Jessica Merchán-Naranjo; Ana González-Pinto; Elena de la Serna; Beatriz Payá; Montserrat Graell; Celso Arango; Mara Parellada Journal: Eur Child Adolesc Psychiatry Date: 2015-03-01 Impact factor: 4.785
Authors: Amy J Lynham; Leon Hubbard; Katherine E Tansey; Marian L Hamshere; Sophie E Legge; Michael J Owen; Ian R Jones; James T R Walters Journal: J Psychiatry Neurosci Date: 2018-04-05 Impact factor: 6.186
Authors: Nikolaos Koutsouleris; Eva M Meisenzahl; Stefan Borgwardt; Anita Riecher-Rössler; Thomas Frodl; Joseph Kambeitz; Yanis Köhler; Peter Falkai; Hans-Jürgen Möller; Maximilian Reiser; Christos Davatzikos Journal: Brain Date: 2015-05-01 Impact factor: 13.501
Authors: Maria Jalbrzikowski; David Freedman; Catherine E Hegarty; Eva Mennigen; Katherine H Karlsgodt; Loes M Olde Loohuis; Roel A Ophoff; Raquel E Gur; Carrie E Bearden Journal: J Am Acad Child Adolesc Psychiatry Date: 2019-01-18 Impact factor: 8.829
Authors: Amy J Lynham; Leon Hubbard; Katherine E Tansey; Marian L Hamshere; Sophie E Legge; Michael J Owen; Ian R Jones; James T R Walters Journal: J Psychiatry Neurosci Date: 2018-07 Impact factor: 6.186
Authors: Maria Giuseppina Ledda; Anna Lisa Fratta; Manuela Pintor; Alessandro Zuddas; Carlo Cianchetti Journal: Child Psychiatry Hum Dev Date: 2009-03-12