| Literature DB >> 11059750 |
C Sweeney1, G Y McClure, M Y Fares, A Stone, B F Coles, P A Thompson, S Korourian, L F Hutchins, F F Kadlubar, C B Ambrosone.
Abstract
A glutathione S-transferase (GST) P1 polymorphism results in an amino acid substitution, Ile105Val; the Val-containing enzyme has reduced activity toward alkylating agents. Cancer patients with the variant enzyme may differ in removal of treatment agents and in outcomes of therapy. We evaluated survival according to GSTP1 genotype among women (n = 240) treated for breast cancer. Women with the low-activity Val/Val genotype had better survival. Compared with Ile/Ile, hazard ratios for overall survival were 0.8 (95% confidence interval, 0.5-1.3) for Ile/Val and 0.3 (95% confidence interval, 0.1-1.0) for Val/Val (P for trend = 0.04). Inherited metabolic variability may influence treatment outcomes.Entities:
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Year: 2000 PMID： 11059750
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701