Literature DB >> 11058785

Frontiers in chemical genetics.

B R Stockwell1.   

Abstract

New methods enable the identification of compounds that both induce a specific cellular state and lead to identification of proteins that regulate that state. Together, developments in three critical areas: chemical diversity, phenotype-based screening and target identification, enable the systematic application of this chemical genetic approach to almost any biological problem or disease process.

Mesh：

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Year:  2000        PMID： 11058785     DOI： 10.1016/s0167-7799(00)01499-2

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  14 in total

1.  A systems biology approach to dissection of the effects of small bicyclic peptidomimetics on a panel of saccharomyces cerevisiae mutants.

Authors:  Irene Stefanini; Andrea Trabocchi; Emmanuela Marchi; Antonio Guarna; Duccio Cavalieri
Journal:  J Biol Chem       Date:  2010-05-25       Impact factor: 5.157

Review 2.  Exploring biology with small organic molecules.

Authors:  Brent R Stockwell
Journal:  Nature       Date:  2004-12-16       Impact factor: 49.962

3.  Label-free detection of small-molecule-protein interactions by using nanowire nanosensors.

Authors:  Wayne U Wang; Chuo Chen; Keng-hui Lin; Ying Fang; Charles M Lieber
Journal:  Proc Natl Acad Sci U S A       Date:  2005-02-16       Impact factor: 11.205

4.  Limited proteolysis differentially modulates the stability and subcellular localization of domains of RPGRIP1 that are distinctly affected by mutations in Leber's congenital amaurosis.

Authors:  Xinrong Lu; Mallikarjuna Guruju; John Oswald; Paulo A Ferreira
Journal:  Hum Mol Genet       Date:  2005-03-30       Impact factor: 6.150

5.  Inverse drug screens: a rapid and inexpensive method for implicating molecular targets.

Authors:  Dany S Adams; Michael Levin
Journal:  Genesis       Date:  2006-11       Impact factor: 2.487

Review 6.  Recent advances in peptide nucleic acid for cancer bionanotechnology.

Authors:  Jun-Chen Wu; Qing-Chun Meng; Hong-Mei Ren; Hong-Tao Wang; Jie Wu; Qi Wang
Journal:  Acta Pharmacol Sin       Date:  2017-04-17       Impact factor: 6.150

7.  Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens.

Authors:  Steve N Bailey; David M Sabatini; Brent R Stockwell
Journal:  Proc Natl Acad Sci U S A       Date:  2004-11-08       Impact factor: 11.205

8.  Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism.

Authors:  Mitchell R Lunn; David E Root; Allison M Martino; Stephen P Flaherty; Brian P Kelley; Daniel D Coovert; Arthur H Burghes; Nguyen Thi Man; Glenn E Morris; Jianhua Zhou; Elliot J Androphy; Charlotte J Sumner; Brent R Stockwell
Journal:  Chem Biol       Date:  2004-11

9.  Chemical genetic screening identifies sulfonamides that raise organellar pH and interfere with membrane traffic.

Authors:  Thomas J F Nieland; Yan Feng; Jing Xu Brown; Tuan Daniel Chuang; Peter D Buckett; Jin Wang; Xiao-Song Xie; Timothy E McGraw; Tomas Kirchhausen; Marianne Wessling-Resnick
Journal:  Traffic       Date:  2004-07       Impact factor: 6.215

10.  Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila.

Authors:  Xavier Charpentier; Joëlle E Gabay; Moraima Reyes; Jing W Zhu; Arthur Weiss; Howard A Shuman
Journal:  PLoS Pathog       Date:  2009-07-03       Impact factor: 6.823
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