Literature DB >> 1105662

Effect of irradiation on immune responses.

C C Stewart, C A Perez.   

Abstract

The radioresistance of antibody-mediated immune response is lowest when radiation is given before antigen, and rises steadily with time after antigen stimulation to reach a maximum when serum antibody is at a maximum, suggesting that antibody-producing cells are highly resistant. Irradiation affects the antibody-mediated response by 1) lengthening the period between stimulation and production of detectabel levels of serum antibody, 2) decreasing the rate of increase in serum antibody levls, and 3) decreasing the maximum concentration of serum antibody. Irradiation affects the cell-mediated response by inhibiting immunization and delayed hypersensitivity reactions when administered before antigen. Because the cell-mediated response involves nonlymphoid cells whose precursors are also radiosensitive, irradiation following stimulation may also produce temporary suppression.

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Year:  1976        PMID： 1105662     DOI： 10.1148/118.1.201

Source DB:  PubMed          Journal:  Radiology        ISSN： 0033-8419            Impact factor:   11.105


  8 in total

1.  Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma.

Authors:  Ayman Oweida; Shelby Lennon; Dylan Calame; Sean Korpela; Shilpa Bhatia; Jaspreet Sharma; Caleb Graham; David Binder; Natalie Serkova; David Raben; Lynn Heasley; Eric Clambey; Raphael Nemenoff; Sana D Karam
Journal:  Oncoimmunology       Date:  2017-08-03       Impact factor: 8.110

2.  Adjuvant therapy with agonistic antibodies to CD134 (OX40) increases local control after surgical or radiation therapy of cancer in mice.

Authors:  Michael J Gough; Marka R Crittenden; MaryClare Sarff; Puiyi Pang; Steven K Seung; John T Vetto; Hong-Ming Hu; William L Redmond; John Holland; Andrew D Weinberg
Journal:  J Immunother       Date:  2010-10       Impact factor: 4.456

3.  Effect of selenium in recovery of immunity damaged by H2O2 and 60Co radiation.

Authors:  E Sun; H Xu; Q Liu; J Zhou; P Zuo; J Wang
Journal:  Biol Trace Elem Res       Date:  1995-06       Impact factor: 3.738

4.  Immunological monitoring of patients affected by anaplastic glioma concerning in effects of surgery, radio-, and chemotherapy. A preliminary report.

Authors:  F Servadei; R Parente; F Spagnolli; G Gaist; R Padovani; M Bucci; L Steiner
Journal:  Acta Neurochir (Wien)       Date:  1982       Impact factor: 2.216

Review 5.  The impact of the myeloid response to radiation therapy.

Authors:  Michael J Gough; Kristina Young; Marka Crittenden
Journal:  Clin Dev Immunol       Date:  2013-04-07

6.  Extracting gene networks for low-dose radiation using graph theoretical algorithms.

Authors:  Brynn H Voy; Jon A Scharff; Andy D Perkins; Arnold M Saxton; Bhavesh Borate; Elissa J Chesler; Lisa K Branstetter; Michael A Langston
Journal:  PLoS Comput Biol       Date:  2006-07-21       Impact factor: 4.475

7.  A hypofractionated radiation regimen avoids the lymphopenia associated with neoadjuvant chemoradiation therapy of borderline resectable and locally advanced pancreatic adenocarcinoma.

Authors:  Todd Crocenzi; Benjamin Cottam; Pippa Newell; Ronald F Wolf; Paul D Hansen; Chet Hammill; Matthew C Solhjem; Yue-Yun To; Amy Greathouse; Garth Tormoen; Zeljka Jutric; Kristina Young; Keith S Bahjat; Michael J Gough; Marka R Crittenden
Journal:  J Immunother Cancer       Date:  2016-08-16       Impact factor: 13.751

8.  Lymphocyte-Sparing Effect of Proton Therapy in Patients with Esophageal Cancer Treated with Definitive Chemoradiation.

Authors:  Penny Fang; Yutaka Shiraishi; Vivek Verma; Wen Jiang; Juhee Song; Brian P Hobbs; Steven H Lin
Journal:  Int J Part Ther       Date:  2018
  8 in total

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