F K Habib1, M Ross, C W Bayne. 1. Prostate Research Group, University Department of Oncology, Western General Hospital, Edinburgh, Scotland, UK. fouad.habib@ed.ak.uk
Abstract
BACKGROUND: The search for novel agents for the treatment of the lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) is dependent on an increased understanding of the pathophysiology of the disease. Unfortunately, in vitro and animal models have been of limited value. METHODS: This article describes a novel model system in which the interactions of the stromal and epithelial components of the prostate gland can be determined. RESULTS: The coculture system provides a simple model of the cellular interactions occurring in the adult human prostate. CONCLUSIONS: This coculture system could potentially be used to determine the precise molecular site of action of agents such as terazosin on prostatic apoptosis. Copyright 2000 Wiley-Liss, Inc.
BACKGROUND: The search for novel agents for the treatment of the lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) is dependent on an increased understanding of the pathophysiology of the disease. Unfortunately, in vitro and animal models have been of limited value. METHODS: This article describes a novel model system in which the interactions of the stromal and epithelial components of the prostate gland can be determined. RESULTS: The coculture system provides a simple model of the cellular interactions occurring in the adult human prostate. CONCLUSIONS: This coculture system could potentially be used to determine the precise molecular site of action of agents such as terazosin on prostatic apoptosis. Copyright 2000 Wiley-Liss, Inc.
Authors: Daisy Carbajal; Maria de Lourdes Arruzazabala; Más Rosa; Vivian Molina; Eduardo Rodríguez; Victor González Journal: Curr Ther Res Clin Exp Date: 2004-11