Literature DB >> 11056205

Effects of the Na(+)/H(+) exchanger monensin on intracellular pH in astroglia.

Y Itoh1, M J Law, L Sokoloff.   

Abstract

Stimulation of astroglial glucose utilization by the Na(+)/H(+) exchanger monensin is only partially blocked by ouabain. The present studies show that monensin also raises intracellular pH in astroglia. Because increased pH stimulates phosphofructokinase activity, the ouabain-insensitive portion of the stimulation of cerebral glucose utilization (CMR(glc)) appears to be due to stimulation of glycolysis by intracellular alkalinization.

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Year:  2000        PMID： 11056205     DOI： 10.1016/s0006-8993(00)02822-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  2 in total

1.  Na(+)/K(+) pump interacts with the h-current to control bursting activity in central pattern generator neurons of leeches.

Authors:  Daniel Kueh; William H Barnett; Gennady S Cymbalyuk; Ronald L Calabrese
Journal:  Elife       Date:  2016-09-02       Impact factor: 8.140

2.  Brain lactate responses during visual stimulation in fasting and hyperglycemic subjects: a proton magnetic resonance spectroscopy study at 1.5 Tesla.

Authors:  Richard J Maddock; Michael H Buonocore; Shawn P Lavoie; Linda E Copeland; Shawn J Kile; Anne L Richards; John M Ryan
Journal:  Psychiatry Res       Date:  2006-10-03       Impact factor: 3.222
  2 in total

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