Literature DB >> 11055809

Toxicity of cisplatin to the central nervous system of male rabbits.

K Namikawa1, M Asakura, T Minami, Y Okazaki, E Kadota, S Hashimoto.   

Abstract

The cytotoxic effects of platinum (Pt) were studied by intraparenchymal injection of 1 mg of cisplatin (CDDP) in male rabbits. Time-serial plasma Pt levels were used as CDDP clearance indices in brain and kidney tissues. The tissue samples were also examined histologically. Changes in the blood-brain barrier (BBB) were evaluated by horseradish peroxidase (HRP) extravasation. In the brain infusion group, Pt was detected in the plasma 30 min after the start of infusion. In the kidney, Pt was detected after 10 min of CDDP injection. The maximum plasma concentration of Pt in the brain group showed diffuse edema, neuronal necrosis, karyolysis, and HRP extravasation around the injection site. In contrast, the histological damage to kidneys was minimal. The results presented here show that direct infusion of CDDP caused the most extensive cytotoxicity in the brain. The low clearance rate of CDDP from the brain and BBB disruption may explain this behavior.

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Year:  2000        PMID： 11055809     DOI： 10.1385/BTER:74:3:223

Source DB:  PubMed          Journal:  Biol Trace Elem Res        ISSN： 0163-4984            Impact factor:   3.738


  9 in total

1.  The effect of some natural antioxidants against cisplatin-induced neurotoxicity in rats: behavioral testing.

Authors:  Mohamed A Kandeil; Safaa B Gomaa; Mohamed O Mahmoud
Journal:  Heliyon       Date:  2020-08-26

Review 2.  Platinum-induced neurotoxicity and preventive strategies: past, present, and future.

Authors:  Abolfazl Avan; Tjeerd J Postma; Cecilia Ceresa; Amir Avan; Guido Cavaletti; Elisa Giovannetti; Godefridus J Peters
Journal:  Oncologist       Date:  2015-03-12

3.  Developing central nervous system and vulnerability to platinum compounds.

Authors:  G Bernocchi; M G Bottone; V M Piccolini; V Dal Bo; G Santin; S A De Pascali; D Migoni; F P Fanizzi
Journal:  Chemother Res Pract       Date:  2011-02-15

4.  Platinum sensitivity and CD133 expression as risk and prognostic predictors of central nervous system metastases in patients with epithelial ovarian cancer.

Authors:  Bo-Lin Liu; Shu-Juan Liu; Andrius Baskys; Hong Cheng; Ying Han; Chao Xie; Hui Song; Jia Li; Xiao-Yan Xin
Journal:  BMC Cancer       Date:  2014-11-17       Impact factor: 4.430

5.  Brain-sparing methods for IMRT of head and neck cancer.

Authors:  Alex Dunlop; Liam Welsh; Dualta McQuaid; Jamie Dean; Sarah Gulliford; Vibeke Hansen; Shreerang Bhide; Chris Nutting; Kevin Harrington; Kate Newbold
Journal:  PLoS One       Date:  2015-03-17       Impact factor: 3.240

Review 6.  Cannabinoids and agmatine as potential therapeutic alternatives for cisplatin-induced peripheral neuropathy.

Authors:  Basak Donertas; Cigdem Cengelli Unel; Kevser Erol
Journal:  J Exp Pharmacol       Date:  2018-06-22

Review 7.  Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity.

Authors:  Wen Gao; Lin Guo; Yan Yang; Yu Wang; Shuang Xia; Hui Gong; Bi-Kui Zhang; Miao Yan
Journal:  Front Cell Dev Biol       Date:  2022-02-02

8.  Neurotoxic Effects of Platinum Compounds: Studies in vivo on Intracellular Calcium Homeostasis in the Immature Central Nervous System.

Authors:  Graziella Bernocchi; Francesco P Fanizzi; Sandra A De Pascali; Valeria M Piccolini; Caterina Gasperini; Violetta Insolia; Maria Grazia Bottone
Journal:  Toxics       Date:  2015-06-19

9.  Trypanocidal Effects of Cisplatin alone and in Combination with Nigella sativa Oil on Experimentally Infected Mice with Trypanosoma evansi.

Authors:  Nashaat Abd El-Monem Nassef; Manal Ahmed El-Melegy; Engy Victor Beshay; Dalia Rifaat Al-Sharaky; Tahany Mohamed Al-Attar
Journal:  Iran J Parasitol       Date:  2018 Jan-Mar       Impact factor: 1.012
  9 in total

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