Literature DB >> 11055358

Chemical modification of nodulisporic acid A: preliminary structure-activity relationships.

P T Meinke1, M B Ayer, S L Colletti, C Li, J Lim, D Ok, S Salva, D M Schmatz, T L Shih, W L Shoop, L M Warmke, M J Wyvratt, M Zakson-Aiken, M H Fisher.   

Abstract

Medicinal chemistry efforts were initiated to identify the key constituents of the nodulisporic acid A (1) pharmacophore that are integral to its potent insecticidal activity. New semisynthetic derivatives delineated 1 into 'permissive' and 'nonpermissive' regions and led to the discovery of new nodulisporamides with significantly improved flea efficacy.

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Year:  2000        PMID： 11055358     DOI： 10.1016/s0960-894x(00)00469-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin.

Authors:  N S Kane; B Hirschberg; S Qian; D Hunt; B Thomas; R Brochu; S W Ludmerer; Y Zheng; M Smith; J P Arena; C J Cohen; D Schmatz; J Warmke; D F Cully
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

2.  Total Synthesis of (-)-Nodulisporic Acids D, C, and B: Evolution of a Unified Synthetic Strategy.

Authors:  Yike Zou; Xiangqin Li; Yun Yang; Simon Berritt; Jason Melvin; Stephen Gonzales; Matthew Spafford; Amos B Smith
Journal:  J Am Chem Soc       Date:  2018-07-20       Impact factor: 15.419

3.  Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte.

Authors:  Gerald F Bills; Victor González-Menéndez; Jesús Martín; Gonzalo Platas; Jacques Fournier; Derek Peršoh; Marc Stadler
Journal:  PLoS One       Date:  2012-10-09       Impact factor: 3.240
  3 in total

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