Literature DB >> 11055343

(E) -6-(1-alkyloxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones: synthesis, cytotoxic activity and antitumor activity.

Y J You1, Y Kim, G Y Song, B Z Ahn.   

Abstract

All of 13 (E)-6-(1-alkyloxyiminomethyl)-5,8-dimethoxy-1,4-naphthoquinone derivatives synthesized showed high ED50 values, ranging from 0.1 to 0.3 microg/mL against L1210 cells. However, they were inactive on A549 cells. Nine compounds exhibited higher T/C (%) values (318-388%) than Adriamycin (T/C, 315%).

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Year:  2000        PMID： 11055343     DOI： 10.1016/s0960-894x(00)00447-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

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Journal:  Iran Red Crescent Med J       Date:  2012-02-01       Impact factor: 0.611

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Journal:  Biomed Res Int       Date:  2022-08-21       Impact factor: 3.246
  2 in total

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