| Literature DB >> 11055339 |
E R Parmee1, L L Brockunier, J He, S B Singh, M R Candelore, M A Cascieri, L Deng, Y Liu, L Tota, M J Wyvratt, M H Fisher, A E Weber.
Abstract
Tetrahydroisoquinoline derivatives containing a 4-(hexylureido)benzenesulfonamide were examined as human beta3 adrenergic receptor (AR) agonists. Notably, 4,4-biphenyl derivative 9 was a 6 nM full agonist of the beta3 AR. Naphthyloxy compound 18 (beta3 EC50 = 78 nM) did not activate the beta1 and beta2 ARs at 10 microM, and showed >1000-fold selectivity over binding to the beta1 and beta2 ARs.Entities:
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Year: 2000 PMID： 11055339 DOI： 10.1016/s0960-894x(00)00459-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823