Literature DB >> 11055337

Synthesis and preliminary analysis of a P-glycoprotein-specific [3H]-benzophenone photoaffinity label based on (-)-stipiamide.

M B Andrus1, T M Turner, Z E Sauna, S V Ambudkar.   

Abstract

A benzophenone photoaffinity label 9 based on the polyene natural product (-)-stipiamide has been constructed using a diaminoethane spacer and the radioactive agent [3H]-BZDC (N-succinimidyl p-benzoyl-(2,3-3H)-dehydrocinnamate). Photoaffinity experiments show specific binding to human P-glycoprotein (Pgp) in the presence of cis-flupentixol but not with cyclosporin A.

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Year:  2000        PMID： 11055337     DOI： 10.1016/s0960-894x(00)00439-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Parguerene and precarriebowmide, two classes of lipopeptides from the marine cyanobacterium Moorea producens.

Authors:  Emily Mevers; Tara Byrum; William H Gerwick
Journal:  J Nat Prod       Date:  2013-09-17       Impact factor: 4.050

Review 2.  Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators.

Authors:  Ahmad R Safa
Journal:  Curr Med Chem Anticancer Agents       Date:  2004-01

3.  Mechanism of action of the mannopeptimycins, a novel class of glycopeptide antibiotics active against vancomycin-resistant gram-positive bacteria.

Authors:  Alexey Ruzin; Guy Singh; Anatoly Severin; Youjun Yang; Russell G Dushin; Alan G Sutherland; Albert Minnick; Michael Greenstein; Michael K May; David M Shlaes; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2004-03       Impact factor: 5.191
  3 in total

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