Literature DB >> 11055330

Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists.

Y Wang1, S Chackalamannil, Z Hu, J W Clader, W Greenlee, W Billard, H Binch, G Crosby, V Ruperto, R A Duffy, R McQuade, J E Lachowicz.   

Abstract

Identification of a number of highly potent M2 receptor antagonists with >100-fold selectivity against the M1 and M3 receptor subtypes is described. In the rat microdialysis assay, this series of compounds showed pronounced enhancement of brain acetylcholine release after oral administration.

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Year:  2000        PMID： 11055330     DOI： 10.1016/s0960-894x(00)00457-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  One-pot synthesis of unsymmetrical diaryl thioethers by palladium-catalyzed coupling of two aryl bromides and a thiol surrogate.

Authors:  Manuel A Fernández-Rodríguez; John F Hartwig
Journal:  Chemistry       Date:  2010-02-22       Impact factor: 5.236

2.  Copper Mediated Coupling of 2-(Piperazine)-pyrimidine Iodides with Aryl Thiols using Cu(I)Thiophene-2-carboxylate.

Authors:  Liza Shrestha; Hardik J Patel; Yanlong Kang; Sahil Sharma; Gabriela Chiosis; Tony Taldone
Journal:  Tetrahedron Lett       Date:  2017-10-23       Impact factor: 2.415

3.  A template free protocol for fabrication of a Ni(ii)-loaded magnetically separable nanoreactor scaffold for confined synthesis of unsymmetrical diaryl sulfides in water.

Authors:  Gunjan Arora; Manavi Yadav; Rashmi Gaur; Radhika Gupta; Pooja Rana; Priya Yadav; Rakesh Kumar Sharma
Journal:  RSC Adv       Date:  2020-05-21       Impact factor: 4.036

Review 4.  Transition metal catalyzed synthesis of aryl sulfides.

Authors:  Chad C Eichman; James P Stambuli
Journal:  Molecules       Date:  2011-01-17       Impact factor: 4.411

5.  Site-Selective Suzuki-Miyaura and Sonogashira Cross Coupling Reactions of the Bis(triflate) of 2,4'-Bis(hydroxy)diphenyl Sulfone.

Authors:  Rasheed Ahmad Khera; Asad Ali; Munawar Hussain; Muhammad Farooq Ibad; Alexander Villinger; Peter Langer
Journal:  ChemCatChem       Date:  2012-02-01       Impact factor: 5.686

6.  CuO hollow nanosphere-catalyzed cross-coupling of aryl iodides with thiols.

Authors:  Hyunje Woo; Balaji Mohan; Eunjung Heo; Ji Chan Park; Hyunjoon Song; Kang Hyun Park
Journal:  Nanoscale Res Lett       Date:  2013-09-17       Impact factor: 4.703

7.  First synthesis of 4-(arylsulfonyl)phenols by regioselective [3+3] cyclocondensations of 1,3-bis(silyloxy)-1,3-butadienes with 2-arylsulfonyl-3-ethoxy-2-en-1-ones.

Authors:  Abdolmajid Riahi; Mohanad Shkoor; Olumide Fatunsin; Mathias Lubbe; Helmut Reinke; Peter Langer
Journal:  Tetrahedron Lett       Date:  2008-11-01       Impact factor: 2.415
  7 in total

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