Literature DB >> 11054275

cDNA cloning of biologically active chicken interleukin-18.

K Schneider1, F Puehler, D Baeuerle, S Elvers, P Staeheli, B Kaspers, K C Weining.   

Abstract

By searching a chicken EST database, we identified a cDNA clone that appeared to contain the entire open reading frame (ORF) of chicken interleukin-18 (ChIL-18). The encoded protein consists of 198 amino acids and exhibits approximately 30% sequence identity to IL-18 of humans and various others mammals. Sequence comparisons reveals a putative caspase-1 cleavage site at aspartic acid 29 of the primary translation product, indicating that mature ChIL-18 might consist of 169 amino acids. Bacterially expressed ChIL-18 in which the N-terminal 29 amino acids of the putative precursor molecule were replaced by a histidine tag induced the synthesis of interferon-gamma (IFN-gamma) in cultured primary chicken spleen cells, indicating that the recombinant protein is biologically active.

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Year:  2000        PMID： 11054275     DOI： 10.1089/10799900050163244

Source DB:  PubMed          Journal:  J Interferon Cytokine Res        ISSN： 1079-9907            Impact factor:   2.607


  16 in total

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Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

Review 2.  Innate immunity in vertebrates: an overview.

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Journal:  Immunology       Date:  2016-04-05       Impact factor: 7.397

3.  Expressed sequence tag analysis of Eimeria-stimulated intestinal intraepithelial lymphocytes in chickens.

Authors:  Wongi Min; Hyun S Lillehoj; Christopher M Ashwell; Curtis P van Tassell; Rami A Dalloul; Lakshmi K Matukumalli; Jae Y Han; Erik P Lillehoj
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4.  A eukaryotic expression plasmid carrying chicken interleukin-18 enhances the response to newcastle disease virus vaccine.

Authors:  Chen Wang; Xiaokang Li; Chunjie Zhang; Tingcai Wu; Yinju Li; Xiangchao Cheng
Journal:  Clin Vaccine Immunol       Date:  2014-10-29

5.  Protective immunity against Eimeria acervulina following in ovo immunization with a recombinant subunit vaccine and cytokine genes.

Authors:  Xicheng Ding; Hyun S Lillehoj; Marco A Quiroz; Erich Bevensee; Erik P Lillehoj
Journal:  Infect Immun       Date:  2004-12       Impact factor: 3.441

6.  Differential cytokine mRNA expression in heterophils isolated from Salmonella-resistant and -susceptible chickens.

Authors:  Christina L Swaggerty; Michael H Kogut; Pamela J Ferro; Lisa Rothwell; Igal Y Pevzner; Pete Kaiser
Journal:  Immunology       Date:  2004-09       Impact factor: 7.397

Review 7.  The chicken IL-1 family: evolution in the context of the studied vertebrate lineage.

Authors:  Mark S Gibson; Pete Kaiser; Mark Fife
Journal:  Immunogenetics       Date:  2014-05-27       Impact factor: 2.846

8.  Immunization with recombinant rabies virus expressing Interleukin-18 exhibits enhanced immunogenicity and protection in mice.

Authors:  Weiwei Gai; Wenwen Zheng; Chong Wang; Gary Wong; Yanyan Song; Xuexing Zheng
Journal:  Oncotarget       Date:  2017-09-16

9.  In situ hybridization to detect and localize signature cytokines of T-helper (Th) 1 and Th2 immune responses in chicken tissues.

Authors:  Fana Alem Kidane; Ivana Bilic; Taniya Mitra; Patricia Wernsdorf; Michael Hess; Dieter Liebhart
Journal:  Vet Immunol Immunopathol       Date:  2016-05-12       Impact factor: 2.046

10.  Modulation of Humoral and Cell-Mediated Immunity Against Avian Influenza and Newcastle Disease Vaccines by Oral Administration of Salmonella enterica Serovar Typhimurium Expressing Chicken Interleukin-18.

Authors:  Md Masudur Rahman; Erdenebileg Uyangaa; Seong Kug Eo
Journal:  Immune Netw       Date:  2013-02-28       Impact factor: 6.303
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