Literature DB >> 11054090

Th1 and Th2 cytokines in a patient with Evans' syndrome and profound lymphopenia.

M Karakantza1, A Mouzaki, M Theodoropoulou, J B Bussel, A Maniatis.   

Abstract

A case of Evans' syndrome with IgM deficiency and lymphopenia was studied before and after splenectomy. The lymphopenia was as a result of profound reduction of CD4 and CD8 cells. Study of cytokine secretion before splenectomy revealed a spontaneous Th1- and Th2-type cytokine production, and complete suppression of transforming growth factor (TGF)-beta. After splenectomy, the patient achieved clinical remission, the natural killer (NK) cell number increased and the pattern of cytokine production showed normalization of interleukin (IL)-2, IL-4, IL-10, TGF-beta and abolition of interferon (IFN)-gamma production. We conclude that splenectomy had a beneficial effect owing to an increase in NK cells and an associated increase in TGF-beta production.

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Year:  2000        PMID： 11054090     DOI： 10.1046/j.1365-2141.2000.02296.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  9 in total

1.  Synchronous splenectomy and hepatectomy for patients with hepatocellular carcinoma and hypersplenism: A case-control study.

Authors:  Xiao-Yun Zhang; Chuan Li; Tian-Fu Wen; Lu-Nan Yan; Bo Li; Jia-Yin Yang; Wen-Tao Wang; Li Jiang
Journal:  World J Gastroenterol       Date:  2015-02-28       Impact factor: 5.742

2.  Clinical Features of Systemic Lupus Erythematosus Patients Complicated With Evans Syndrome: A Case-Control, Single Center Study.

Authors:  Lili Zhang; Xiuhua Wu; Laifang Wang; Jing Li; Hua Chen; Yan Zhao; Wenjie Zheng
Journal:  Medicine (Baltimore)       Date:  2016-04       Impact factor: 1.889

3.  Synchronous splenectomy and hepatectomy for patients with small hepatocellular carcinoma and pathological spleen: neutrophil to lymphocyte ratio changes can predict the prognosis.

Authors:  Xiaoyun Zhang; Chuan Li; Tianfu Wen; Wei Peng; Lunan Yan; Bo Li; Jiayin Yang; Wentao Wang; Mingqing Xu; Yong Zeng
Journal:  Oncotarget       Date:  2017-07-11

4.  Evans Syndrome in Childhood: Long Term Follow-Up and the Evolution in Primary Immunodeficiency or Rheumatological Disease.

Authors:  Beatrice Rivalta; Daniele Zama; Giovanni Pancaldi; Elena Facchini; Maria Elena Cantarini; Angela Miniaci; Arcangelo Prete; Andrea Pession
Journal:  Front Pediatr       Date:  2019-07-23       Impact factor: 3.418

5.  Impact of splenomegaly and splenectomy on prognosis in hepatocellular carcinoma with portal vein tumor thrombus treated with hepatectomy.

Authors:  Zong-Tao Chai; Xiu-Ping Zhang; Min Shao; Jian-Yang Ao; Zhen-Hua Chen; Fan Zhang; Yi-Ren Hu; Cheng-Qian Zhong; Jian-Hua Lin; Kun-Peng Fang; Meng-Chao Wu; Wan Yee Lau; Shu-Qun Cheng
Journal:  Ann Transl Med       Date:  2021-02

6.  Platelet-derived TGF-β1 is related to portal vein thrombosis in cirrhosis by promoting hypercoagulability and endothelial dysfunction.

Authors:  Siyu Jiang; Yingjie Ai; Liyuan Ni; Ling Wu; Xiaoquan Huang; Shiyao Chen
Journal:  Front Cardiovasc Med       Date:  2022-09-26

7.  Evans syndrome associated with sterile inflammation of the central nervous system: a case report.

Authors:  Ole Jan Simon; Tanja Kuhlmann; Stefan Bittner; Carsten Müller-Tidow; Jochen Weigt; Heinz Wiendl; Sven G Meuth
Journal:  J Med Case Rep       Date:  2013-12-03

Review 8.  Evans syndrome: clinical perspectives, biological insights and treatment modalities.

Authors:  José Carlos Jaime-Pérez; Patrizia Elva Aguilar-Calderón; Lorena Salazar-Cavazos; David Gómez-Almaguer
Journal:  J Blood Med       Date:  2018-10-10

9.  Improved survival following splenectomy combined with curative treatments for hepatocellular carcinoma in Child B patients: A propensity score matching study.

Authors:  Youliang Pei; Zhanguo Zhang; Abdoul-Aziz Mba'nbo-Koumpa; Xiaoping Chen; Wanguang Zhang
Journal:  Hepatol Res       Date:  2019-01-04       Impact factor: 4.288
  9 in total

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