| Literature DB >> 11052864 |
M de Lana1, A da Silviera Pinto, B Bastrenta, C Barnabé, S Noël, M Tibayrenc.
Abstract
Eight Trypanosoma cruzi stocks pertaining to the clonal genotypes 19/20, 32, and 39 have been characterized for three experimental parameters of infectivity in Balb/c mice: (i) percentage of mice with a patent parasitemia (% MPP), (ii) maximum parasitemia (MP), and (iii) percentage of mice with positive hemoculture (% MPH). By order of decreasing values, the values recorded for the clonal genotypes ranked as follows: 19/20, 32, and 39, except for the % MPP parameter, for which 19/20 and 32 were not statistically different. The rate of successful reisolation after infection in mice, analyzed by multilocus enzyme electrophoresis and random amplified polymorphic DNA typing, was statistically different according to the clonal genotype and was different for uniclonal infections and for mixed infections by two different clonal genotypes. These results confirm that T. cruzi clonal genotypes differ significantly in their infectivity in mice. Copyright 2000 Academic Press.Entities:
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Year: 2000 PMID： 11052864 DOI： 10.1006/expr.2000.4552
Source DB: PubMed Journal: Exp Parasitol ISSN： 0014-4894 Impact factor: 2.011