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Literature DB >> 11052222

Molecular effects of dopamine on striatal-projection pathways.

Abstract

Gene regulation studies demonstrate that dopamine differentially regulates the direct and indirect projection neurons of the striatum through their respective expression of the D1 and D2 dopamine receptors. Induction of immediate-early genes (IEGs) in striatal neurons is used to study dopamine-receptor-mediated neuronal plasticity. In the dopamine-depleted striatum there is a switch in receptor-mediated signal transduction mechanisms to produce a supersensitive form of D1- mediated neuronal plasticity. This switch is suggested to underlie dopamine-agonist-induced dyskinetic movements that develop during the treatment of Parkinson's disease.

Entities: Chemical Disease Gene

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Year: 2000 PMID： 11052222 DOI： 10.1016/s1471-1931(00)00019-7

Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837

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Cited

89 in total

1. Opposite influences of endogenous dopamine D1 and D2 receptor activation on activity states and electrophysiological properties of striatal neurons: studies combining in vivo intracellular recordings and reverse microdialysis.

Authors: Anthony R West; Anthony A Grace
Journal: J Neurosci Date: 2002-01-01 Impact factor: 6.167

2. Effects of prenatal exposure to methylmercury on dopamine-mediated locomotor activity and dopamine D2 receptor binding.

Authors: Elisabetta Daré; Serguei Fetissov; Tomas Hökfelt; Håkan Hall; Sven Ove Ogren; Sandra Ceccatelli
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2003-04-09 Impact factor: 3.000

Molecular effects of dopamine on striatal-projection pathways.

1. Opposite influences of endogenous dopamine D1 and D2 receptor activation on activity states and electrophysiological properties of striatal neurons: studies combining in vivo intracellular recordings and reverse microdialysis.

2. Effects of prenatal exposure to methylmercury on dopamine-mediated locomotor activity and dopamine D2 receptor binding.

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