Literature DB >> 11051563

Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features.

P A Williams1, J Cosme, V Sridhar, E F Johnson, D E McRee.   

Abstract

Although microsomal P450s represent the majority of P450s, only microbial P450s have been amenable to crystal structure solution. We have recently solved the first crystal structure of a microsomal P450, 2C5, a progesterone hydroxylase from rabbit. We discuss the features of the protein in common with existing structures of microbial P450s and limitations of homology modeling mammalian P450s based on the microbial structures. Unique features involving membrane, substrate and cytochrome P450 reductase interactions are also discussed.

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Year:  2000        PMID： 11051563     DOI： 10.1016/s0162-0134(00)00102-1

Source DB:  PubMed          Journal:  J Inorg Biochem        ISSN： 0162-0134            Impact factor:   4.155


  19 in total

Review 1.  Conformational plasticity and structure/function relationships in cytochromes P450.

Authors:  Thomas C Pochapsky; Sophia Kazanis; Marina Dang
Journal:  Antioxid Redox Signal       Date:  2010-10       Impact factor: 8.401

2.  CYP2E1 active site residues in substrate recognition sequence 5 identified by photoaffinity labeling and homology modeling.

Authors:  Samuel L Collom; Arvind P Jamakhandi; Alan J Tackett; Anna Radominska-Pandya; Grover P Miller
Journal:  Arch Biochem Biophys       Date:  2006-11-02       Impact factor: 4.013

3.  Effect of conformational dynamics on substrate recognition and specificity as probed by the introduction of a de novo disulfide bond into cytochrome P450 2B1.

Authors:  Haoming Zhang; Cesar Kenaan; Djemel Hamdane; Gaston Hui Bon Hoa; Paul F Hollenberg
Journal:  J Biol Chem       Date:  2009-07-15       Impact factor: 5.157

4.  Modification of small molecules by using cytochrome P450 expressed in Escherichia coli.

Authors:  Tomohide Uno; Atsushi Nakao; Satoko Masuda; Yuuki Taniguchi; Kengo Kanamaru; Hiroshi Yamagata; Masahiko Nakamura; Hiromasa Imaishi; Kiyoharu Oono
Journal:  J Ind Microbiol Biotechnol       Date:  2006-08-05       Impact factor: 3.346

5.  Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme.

Authors:  P Ross Wilderman; Sean C Gay; Hyun-Hee Jang; Qinghai Zhang; C David Stout; James R Halpert
Journal:  FEBS J       Date:  2011-11-25       Impact factor: 5.542

6.  Crystal structure of the human prostacyclin synthase.

Authors:  Chia-Wang Chiang; Hui-Chun Yeh; Lee-Ho Wang; Nei-Li Chan
Journal:  J Mol Biol       Date:  2006-09-20       Impact factor: 5.469

7.  Active site acidic residues and structural analysis of modelled human aromatase: a potential drug target for breast cancer.

Authors:  J Narashima Murthy; M Nagaraju; G Madhavi Sastry; A Raghuram Rao; G Narahari Sastry
Journal:  J Comput Aided Mol Des       Date:  2006-04-22       Impact factor: 3.686

8.  Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution.

Authors:  Sean C Gay; Manish B Shah; Jyothi C Talakad; Keiko Maekawa; Arthur G Roberts; P Ross Wilderman; Ling Sun; Jane Y Yang; Stephanie C Huelga; Wen-Xu Hong; Qinghai Zhang; C David Stout; James R Halpert
Journal:  Mol Pharmacol       Date:  2010-01-08       Impact factor: 4.436

9.  Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli.

Authors:  Effendi Leonard; Mattheos A G Koffas
Journal:  Appl Environ Microbiol       Date:  2007-09-28       Impact factor: 4.792

10.  Functional studies of N-terminally modified CYP2J2 epoxygenase in model lipid bilayers.

Authors:  Daniel R McDougle; Amrita Palaria; Eric Magnetta; Daryl D Meling; Aditi Das
Journal:  Protein Sci       Date:  2013-07       Impact factor: 6.725
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