Literature DB >> 11050460

The scope and potential of vaginal drug delivery.

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Abstract

The vagina, in addition to being a genital organ with functions related to conception, serves as a potential route for drug administration. Mainly used for local action in the cervico-vaginal region, it has the potential of delivering drugs for systemic effects and uterine targeting. Currently available vaginal dosage forms have several limitations, necessitating the need to develop novel drug delivery systems. In addition, consideration of the regulatory aspects and consumer preferences for vaginal formulations is also required in the early stages of development.

Year:  2000        PMID: 11050460     DOI: 10.1016/s1461-5347(00)00296-0

Source DB:  PubMed          Journal:  Pharm Sci Technolo Today        ISSN: 1461-5347


  30 in total

1.  In vitro evaluation of viability, integrity, and inflammation in genital epithelia upon exposure to pharmaceutical excipients and candidate microbicides.

Authors:  Youssef Gali; Olivier Delezay; Joachim Brouwers; Noura Addad; Patrick Augustijns; Thomas Bourlet; Hind Hamzeh-Cognasse; Kevin K Ariën; Bruno Pozzetto; Guido Vanham
Journal:  Antimicrob Agents Chemother       Date:  2010-10-04       Impact factor: 5.191

2.  The effects of inhomogeneous boundary dilution on the coating flow of an anti-HIV microbicide vehicle.

Authors:  Savas Tasoglu; Jennifer J Peters; Su Chan Park; Stéphane Verguet; David F Katz; Andrew J Szeri
Journal:  Phys Fluids (1994)       Date:  2011-09-15       Impact factor: 3.521

Review 3.  Drug transporters in tissues and cells relevant to sexual transmission of HIV: Implications for drug delivery.

Authors:  Minlu Hu; Sravan Kumar Patel; Tian Zhou; Lisa C Rohan
Journal:  J Control Release       Date:  2015-08-13       Impact factor: 9.776

Review 4.  Vaginal drug delivery systems for HIV prevention.

Authors:  Lisa Cencia Rohan; Alexandra B Sassi
Journal:  AAPS J       Date:  2009-02-05       Impact factor: 4.009

5.  A model of transluminal flow of an anti-HIV microbicide vehicle: Combined elastic squeezing and gravitational sliding.

Authors:  Andrew J Szeri; Su Chan Park; Stéphane Verguet; Aaron Weiss; David F Katz
Journal:  Phys Fluids (1994)       Date:  2008-08-21       Impact factor: 3.521

6.  Investigation of the physicochemical and physicomechanical properties of a novel intravaginal bioadhesive polymeric device in the pig model.

Authors:  Valence M K Ndesendo; Viness Pillay; Yahya E Choonara; Lisa C du Toit; Eckhart Buchmann; Leith C R Meyer; Riaz A Khan; Uwe Rosin
Journal:  AAPS PharmSciTech       Date:  2010-05-06       Impact factor: 3.246

Review 7.  Strategies for Prevention and Treatment of Trichomonas vaginalis Infections.

Authors:  Kawthar Bouchemal; Christian Bories; Philippe M Loiseau
Journal:  Clin Microbiol Rev       Date:  2017-07       Impact factor: 26.132

8.  Development and characterization of bioadhesive vaginal films of sodium polystyrene sulfonate (PSS), a novel contraceptive antimicrobial agent.

Authors:  Sanjay Garg; Kavita Vermani; Alka Garg; Robert A Anderson; William B Rencher; Lourens J D Zaneveld
Journal:  Pharm Res       Date:  2005-04-07       Impact factor: 4.200

9.  The involvement of intracellular calcium in the MCT-mediated uptake of lactic acid by HeLa cells.

Authors:  Sravanthi Cheeti; Chi H Lee
Journal:  Mol Pharm       Date:  2010-02-01       Impact factor: 4.939

10.  Mucoadhesive vaginal tablets as veterinary delivery system for the controlled release of an antimicrobial drug, acriflavine.

Authors:  Elisabetta Gavini; Vanna Sanna; Claudia Juliano; Maria Cristina Bonferoni; Paolo Giunchedi
Journal:  AAPS PharmSciTech       Date:  2002       Impact factor: 3.246

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