Literature DB >> 11048639

The mechanism of phospholipase C-gamma1 regulation.

M J Kim1, E Kim, S H Ryu, P G Suh.   

Abstract

Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-gamma1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. In this review, we will focus on the activation mechanism and regulatory function of PLC-gamma1.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 11048639     DOI： 10.1038/emm.2000.18

Source DB:  PubMed          Journal:  Exp Mol Med        ISSN： 1226-3613            Impact factor:   8.718


  15 in total

1.  Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma.

Authors:  Matthew Breen; Jaime F Modiano; Ingegerd Elvers; Kerstin Lindblad-Toh; Kate Megquier; Jason Turner-Maier; Ross Swofford; Jong-Hyuk Kim; Aaron L Sarver; Chao Wang; Sharadha Sakthikumar; Jeremy Johnson; Michele Koltookian; Mitzi Lewellen; Milcah C Scott; Ashley J Schulte; Luke Borst; Noriko Tonomura; Jessica Alfoldi; Corrie Painter; Rachael Thomas; Elinor K Karlsson
Journal:  Mol Cancer Res       Date:  2019-09-30       Impact factor: 5.852

2.  The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion.

Authors:  Ernst J A Steller; Laila Ritsma; Danielle A E Raats; Frederik J H Hoogwater; Benjamin L Emmink; Klaas M Govaert; Jamila Laoukili; Inne H M Borel Rinkes; Jacco van Rheenen; Onno Kranenburg
Journal:  EMBO Rep       Date:  2011-09-01       Impact factor: 8.807

3.  Expression of cholecystokinin-2/gastrin receptor in the murine pancreas modulates cell adhesion and cell differentiation in vivo.

Authors:  Christiane Bierkamp; Stéphanie Bonhoure; Anne Mathieu; Pascal Clerc; Daniel Fourmy; Lucien Pradayrol; Catherine Seva; Marlène Dufresne
Journal:  Am J Pathol       Date:  2004-12       Impact factor: 4.307

4.  Cholesterol modulates ion channels via down-regulation of phosphatidylinositol 4,5-bisphosphate.

Authors:  Yoon Sun Chun; Sora Shin; Yonjung Kim; Hana Cho; Myoung Kyu Park; Tae-Wan Kim; Sergey V Voronov; Gilbert Di Paolo; Byung-Chang Suh; Sungkwon Chung
Journal:  J Neurochem       Date:  2009-12-14       Impact factor: 5.372

5.  Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration.

Authors:  Abhinav Arneja; Hannah Johnson; Laura Gabrovsek; Douglas A Lauffenburger; Forest M White
Journal:  J Immunol       Date:  2013-12-02       Impact factor: 5.422

6.  Role of mTOR downstream effector signaling molecules in Francisella tularensis internalization by murine macrophages.

Authors:  Michael W Edwards; James A Aultman; Gregory Harber; Jay M Bhatt; Elizabeth Sztul; Qingan Xu; Ping Zhang; Suzanne M Michalek; Jannet Katz
Journal:  PLoS One       Date:  2013-12-03       Impact factor: 3.240

7.  ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phospholipase C γ1 and protein kinase C pathways.

Authors:  Cristina Wolf; Yawen Qian; Matthew A Brooke; David P Kelsell; Claus-Werner Franzke
Journal:  Sci Rep       Date:  2016-12-22       Impact factor: 4.379

Review 8.  The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events.

Authors:  Nirdosh Dadwal; Charlie Mix; Annegret Reinhold; Amelie Witte; Christian Freund; Burkhart Schraven; Stefanie Kliche
Journal:  Front Immunol       Date:  2021-07-06       Impact factor: 7.561

9.  Migfilin protein promotes migration and invasion in human glioma through epidermal growth factor receptor-mediated phospholipase C-γ and STAT3 protein signaling pathways.

Authors:  Yunwei Ou; Ling Ma; Lijia Dong; Liying Ma; Zitong Zhao; Li Ma; Wei Zhou; Jing Fan; Chuanyue Wu; Chunjiang Yu; Qimin Zhan; Yongmei Song
Journal:  J Biol Chem       Date:  2012-07-25       Impact factor: 5.157

10.  Host-pathogen systems biology: logical modelling of hepatocyte growth factor and Helicobacter pylori induced c-Met signal transduction.

Authors:  Raimo Franke; Melanie Müller; Nicole Wundrack; Ernst-Dieter Gilles; Steffen Klamt; Thilo Kähne; Michael Naumann
Journal:  BMC Syst Biol       Date:  2008-01-14
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.