| Literature DB >> 1104749 |
Abstract
Experimental amyloidosis in mice can be induced by repeated injections of casein. It has now been demonstrated that casein induces strong polyclonal antibody synthesis in mouse B spleen lymphocytes. This effect is much more pronounced in spleen cells from anyloid-susceptible mice (CBA/J) than amyloid-resistant mice (A/J). It is suggested that amyloidosis can be due in some instances to a constant exposure for molecules which induce polyclonal B-cell activation.Entities:
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Year: 1975 PMID： 1104749 PMCID： PMC2190064 DOI： 10.1084/jem.142.6.1564
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307