| Literature DB >> 11045819 |
M Randić1, M Vracko, A Nandy, S C Basak.
Abstract
In this article we (1) outline the construction of a 3-D "graphical" representation of DNA primary sequences, illustrated on a portion of the human beta globin gene; (2) describe a particular scheme that transforms the above 3-D spatial representation of DNA into a numerical matrix representation; (3) illustrate construction of matrix invariants for DNA sequences; and (4) suggest a data reduction based on statistical analysis of matrix invariants generated for DNA. Each of the four contributions represents a novel development that we hope will facilitate comparative studies of DNA and open new directions for representation and characterization of DNA primary sequences.Entities:
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Year: 2000 PMID： 11045819 DOI： 10.1021/ci000034q
Source DB: PubMed Journal: J Chem Inf Comput Sci ISSN： 0095-2338