| Literature DB >> 11044129 |
W A Bresnahan1, G E Hultman, T Shenk.
Abstract
A cDNA encoding the catalytic subunit of human telomerase was used to generate life-extended derivatives of primary human diploid fibroblasts. The life-extended cells supported efficient human cytomegalovirus (HCMV) replication. A subclone of the life-extended cells was generated containing the HCMV UL82 gene and used to isolate and propagate a virus that exhibited a profound growth defect after infection at a low input multiplicity.Entities:
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Year: 2000 PMID: 11044129 PMCID: PMC110959 DOI: 10.1128/jvi.74.22.10816-10818.2000
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103