Literature DB >> 11044127

Molecular correlates of influenza A H5N1 virus pathogenesis in mice.

J M Katz1, X Lu, T M Tumpey, C B Smith, M W Shaw, K Subbarao.   

Abstract

Highly pathogenic avian influenza A H5N1 viruses caused an outbreak of human respiratory illness in Hong Kong. Of 15 human H5N1 isolates characterized, nine displayed a high-, five a low-, and one an intermediate-pathogenicity phenotype in the BALB/c mouse model. Sequence analysis determined that five specific amino acids in four proteins correlated with pathogenicity in mice. Alone or in combination, these specific residues are the likely determinants of virulence of human H5N1 influenza viruses in this model.

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Year:  2000        PMID： 11044127      PMCID： PMC110957          DOI： 10.1128/jvi.74.22.10807-10810.2000

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  33 in total

1.  Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines.

Authors:  M H Snyder; R F Betts; D DeBorde; E L Tierney; M L Clements; D Herrington; S D Sears; R Dolin; H F Maassab; B R Murphy
Journal:  J Virol       Date:  1988-02       Impact factor: 5.103

2.  Characterization of low virulent strains of highly pathogenic A/Hong Kong/156/97 (H5N1) virus in mice after passage in embryonated hens' eggs.

Authors:  Y Hiromoto; T Saito; S Lindstrom; K Nerome
Journal:  Virology       Date:  2000-07-05       Impact factor: 3.616

3.  Correlation of pathogenicity and gene constellation of influenza A viruses. II. Highly neurovirulent recombinants derived from non-neurovirulent or weakly neurovirulent parent virus strains.

Authors:  C Scholtissek; A Vallbracht; B Flehmig; R Rott
Journal:  Virology       Date:  1979-06       Impact factor: 3.616

4.  Structure of the catalytic and antigenic sites in influenza virus neuraminidase.

Authors:  P M Colman; J N Varghese; W G Laver
Journal:  Nature       Date:  1983 May 5-11       Impact factor: 49.962

5.  Depletion of lymphocytes and diminished cytokine production in mice infected with a highly virulent influenza A (H5N1) virus isolated from humans.

Authors:  T M Tumpey; X Lu; T Morken; S R Zaki; J M Katz
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

6.  Characterization of virulent and avirulent A/chicken/Pennsylvania/83 influenza A viruses: potential role of defective interfering RNAs in nature.

Authors:  W J Bean; Y Kawaoka; J M Wood; J E Pearson; R G Webster
Journal:  J Virol       Date:  1985-04       Impact factor: 5.103

7.  Rescue of an influenza A virus wild-type PB2 gene and a mutant derivative bearing a site-specific temperature-sensitive and attenuating mutation.

Authors:  E K Subbarao; Y Kawaoka; B R Murphy
Journal:  J Virol       Date:  1993-12       Impact factor: 5.103

8.  Glycosylation of neuraminidase determines the neurovirulence of influenza A/WSN/33 virus.

Authors:  S Li; J Schulman; S Itamura; P Palese
Journal:  J Virol       Date:  1993-11       Impact factor: 5.103

9.  A single amino acid in the PB2 gene of influenza A virus is a determinant of host range.

Authors:  E K Subbarao; W London; B R Murphy
Journal:  J Virol       Date:  1993-04       Impact factor: 5.103

10.  Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.

Authors:  A Stieneke-Gröber; M Vey; H Angliker; E Shaw; G Thomas; C Roberts; H D Klenk; W Garten
Journal:  EMBO J       Date:  1992-07       Impact factor: 11.598
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  86 in total

Review 1.  Influenza: emergence and control.

Authors:  Aleksandr S Lipatov; Elena A Govorkova; Richard J Webby; Hiroichi Ozaki; Malik Peiris; Yi Guan; Leo Poon; Robert G Webster
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

2.  Pathogenicity of swine influenza viruses possessing an avian or swine-origin PB2 polymerase gene evaluated in mouse and pig models.

Authors:  Wenjun Ma; Kelly M Lager; Xi Li; Bruce H Janke; Derek A Mosier; Laura E Painter; Eva S Ulery; Jingqun Ma; Porntippa Lekcharoensuk; Richard J Webby; Jürgen A Richt
Journal:  Virology       Date:  2010-11-11       Impact factor: 3.616

3.  Isolation and characterization of avian influenza viruses, including highly pathogenic H5N1, from poultry in live bird markets in Hanoi, Vietnam, in 2001.

Authors:  Doan C Nguyen; Timothy M Uyeki; Samadhan Jadhao; Taronna Maines; Michael Shaw; Yumiko Matsuoka; Catherine Smith; Thomas Rowe; Xiuhua Lu; Henrietta Hall; Xiyan Xu; Amanda Balish; Alexander Klimov; Terrence M Tumpey; David E Swayne; Lien P T Huynh; Ha K Nghiem; Hanh H T Nguyen; Long T Hoang; Nancy J Cox; Jacqueline M Katz
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

4.  Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China.

Authors:  Hualan Chen; Yanbing Li; Zejun Li; Jianzhong Shi; Kyoko Shinya; Guohua Deng; Qiaoling Qi; Guobin Tian; Shufang Fan; Haidan Zhao; Yingxiang Sun; Yoshihiro Kawaoka
Journal:  J Virol       Date:  2006-06       Impact factor: 5.103

5.  Characterization of the complete genome of influenza A (H5N1) virus isolated during the 2006 outbreak in poultry in India.

Authors:  Koninika Ray; Varsha A Potdar; Sarah S Cherian; Shailesh D Pawar; Santosh M Jadhav; Shamal R Waregaonkar; Anshu A Joshi; Akhilesh C Mishra
Journal:  Virus Genes       Date:  2008-01-24       Impact factor: 2.332

6.  Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus.

Authors:  Yong Liu; Kun Qin; Geng Meng; Jinfang Zhang; Jianfang Zhou; Guangyu Zhao; Ming Luo; Xiaofeng Zheng
Journal:  J Biol Chem       Date:  2013-02-22       Impact factor: 5.157

7.  Early control of H5N1 influenza virus replication by the type I interferon response in mice.

Authors:  Kristy J Szretter; Shivaprakash Gangappa; Jessica A Belser; Hui Zeng; Hualan Chen; Yumiko Matsuoka; Suryaprakash Sambhara; David E Swayne; Terrence M Tumpey; Jacqueline M Katz
Journal:  J Virol       Date:  2009-03-18       Impact factor: 5.103

8.  Pathogenesis of 1918 pandemic and H5N1 influenza virus infections in a guinea pig model: antiviral potential of exogenous alpha interferon to reduce virus shedding.

Authors:  Neal Van Hoeven; Jessica A Belser; Kristy J Szretter; Hui Zeng; Peter Staeheli; David E Swayne; Jacqueline M Katz; Terrence M Tumpey
Journal:  J Virol       Date:  2009-01-14       Impact factor: 5.103

9.  Characterization of H5N1 influenza A viruses isolated from domestic green-winged teal.

Authors:  Jianjun Chen; Zhongdong Yang; Quanjiao Chen; Xueying Liu; Fang Fang; Haiyan Chang; Dongmei Li; Ze Chen
Journal:  Virus Genes       Date:  2008-09-30       Impact factor: 2.332

10.  The special neuraminidase stalk-motif responsible for increased virulence and pathogenesis of H5N1 influenza A virus.

Authors:  Hongbo Zhou; Zhengjun Yu; Yong Hu; Jiagang Tu; Wei Zou; Yaping Peng; Jiping Zhu; Yongtao Li; Anding Zhang; Ziniu Yu; Zhiping Ye; Huanchun Chen; Meilin Jin
Journal:  PLoS One       Date:  2009-07-17       Impact factor: 3.240
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