Literature DB >> 11043558

Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression.

C Wang1, C J Billington, A S Levine, C M Kotz.   

Abstract

Cocaine and amphetamine regulated transcript (CART) decreases feeding and body weight after ventricular injection. CART mRNA and peptide are found in the paraventricular nucleus of the hypothalamus (PVN). The purpose of the present study was to determine effects of PVN-injected CART on feeding and thermogenic capacity. PVN-injected CART (55-102, 100 pmol) significantly decreased NPY-induced feeding at 1, 2 and 4 h, but did not significantly affect deprivation-induced feeding. CART induced gene expression of uncoupling protein 1 (UCP1), UCP2, and UCP3 in brown and white adipose tissue and biceps femoris muscle respectively. These results indicate the PVN as a specific site of CART action, and suggest that CART in the PVN may have an important influence on energy metabolism.

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Year:  2000        PMID： 11043558     DOI： 10.1097/00001756-200009280-00040

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  18 in total

Review 1.  CART peptides: regulators of body weight, reward and other functions.

Authors:  G Rogge; D Jones; G W Hubert; Y Lin; M J Kuhar
Journal:  Nat Rev Neurosci       Date:  2008-10       Impact factor: 34.870

2.  Gender differences in Nociceptin/Orphanin FQ-induced food intake in strains derived from rats prone (WOKW) and resistant (Dark Agouti) to metabolic syndrome: a possible involvement of the cocaine- and amphetamine-regulated transcript system.

Authors:  Serena Battistoni; Ingrid Kloting; Carlo Cifani; Maurizio Massi; Carlo Polidori
Journal:  Genes Nutr       Date:  2010-11-13       Impact factor: 5.523

Review 3.  Interacting Neural Processes of Feeding, Hyperactivity, Stress, Reward, and the Utility of the Activity-Based Anorexia Model of Anorexia Nervosa.

Authors:  Rachel A Ross; Yael Mandelblat-Cerf; Anne M J Verstegen
Journal:  Harv Rev Psychiatry       Date:  2016 Nov/Dec       Impact factor: 3.732

4.  Fasting induces CART down-regulation in the zebrafish nervous system in a cannabinoid receptor 1-dependent manner.

Authors:  Shin-Ichi Nishio; Yann Gibert; Liubov Berekelya; Laure Bernard; Frédéric Brunet; Etienne Guillot; Jean-Christophe Le Bail; Juan Antonio Sánchez; Anne Marie Galzin; Gerard Triqueneaux; Vincent Laudet
Journal:  Mol Endocrinol       Date:  2012-06-14

5.  Leanness and heightened nonresting energy expenditure: role of skeletal muscle activity thermogenesis.

Authors:  Chaitanya K Gavini; Sromona Mukherjee; Charu Shukla; Steven L Britton; Lauren G Koch; Haifei Shi; Colleen M Novak
Journal:  Am J Physiol Endocrinol Metab       Date:  2014-01-07       Impact factor: 4.310

6.  Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity.

Authors:  Etsuo Susaki; Chie Kaneko-Oshikawa; Keishi Miyata; Mitsuhisa Tabata; Tetsuya Yamada; Yuichi Oike; Hideki Katagiri; Keiichi I Nakayama
Journal:  J Biol Chem       Date:  2010-02-26       Impact factor: 5.157

7.  Regulation of cocaine- and amphetamine-regulated transcript-synthesising neurons of the hypothalamic paraventricular nucleus by endotoxin; implications for lipopolysaccharide-induced regulation of energy homeostasis.

Authors:  T Füzesi; E Sánchez; G Wittmann; P S Singru; C Fekete; R M Lechan
Journal:  J Neuroendocrinol       Date:  2008-07-08       Impact factor: 3.627

8.  Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats.

Authors:  Tobias Inhoff; Hubert Mönnikes; Steffen Noetzel; Andreas Stengel; Miriam Goebel; Q Thai Dinh; Andrea Riedl; Norbert Bannert; Anna-Sophia Wisser; Bertram Wiedenmann; Burghard F Klapp; Yvette Taché; Peter Kobelt
Journal:  Peptides       Date:  2008-09-30       Impact factor: 3.750

9.  Hindbrain cocaine- and amphetamine-regulated transcript induces hypothermia mediated by GLP-1 receptors.

Authors:  Karolina P Skibicka; Amber L Alhadeff; Harvey J Grill
Journal:  J Neurosci       Date:  2009-05-27       Impact factor: 6.167

10.  Efferent projections of neuropeptide Y-expressing neurons of the dorsomedial hypothalamus in chronic hyperphagic models.

Authors:  Shin J Lee; Melissa Kirigiti; Sarah R Lindsley; Alberto Loche; Christopher J Madden; Shaun F Morrison; M Susan Smith; Kevin L Grove
Journal:  J Comp Neurol       Date:  2013-06-01       Impact factor: 3.215
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