Literature DB >> 11043536

The distribution of the neurokinin B receptor in the human and rat hypothalamus.

Y Koutcherov1, K W Ashwell, G Paxinos.   

Abstract

The neurokinin B receptor (NK3) is an element of the hypothalamic neuronal circuitry regulating blood pressure in rats. The present study used immunohistochemistry to reveal the distribution of NK3 in the human hypothalamus. The strongest NK3-like immunoreactivity in the human hypothalamus was found in neurons of the paraventricular nucleus, specifically in the parvicellular and posterior paraventricular subnuclei. Another prominent population of NK3-positive cells in the human hypothalamus was found in the perifornical nucleus. The present study also showed two previously unreported populations of NK3-positive neurons in the rat periventricular nucleus and medial magnocellular paraventricular subnucleus. It is concluded that there is a large degree of similarity in the distribution of NK3 in the human and rat hypothalamus.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 11043536     DOI： 10.1097/00001756-200009280-00018

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  7 in total

1.  Characterization of RO4583298 as a novel potent, dual antagonist with in vivo activity at tachykinin NK₁ and NK₃ receptors.

Authors:  P Malherbe; F Knoflach; M C Hernandez; T Hoffmann; P Schnider; R H Porter; J G Wettstein; T M Ballard; W Spooren; L Steward
Journal:  Br J Pharmacol       Date:  2011-02       Impact factor: 8.739

2.  Distribution and pharmacological characterization of primate NK-1 and NK-3 tachykinin receptors in the central nervous system of the rhesus monkey.

Authors:  Masatoshi Nagano; Fumihito Saitow; Eisuke Haneda; Shiro Konishi; Motoharu Hayashi; Hidenori Suzuki
Journal:  Br J Pharmacol       Date:  2006-02       Impact factor: 8.739

3.  Interactions between kisspeptins and neurokinin B.

Authors:  Víctor M Navarro
Journal:  Adv Exp Med Biol       Date:  2013       Impact factor: 2.622

4.  Function and pharmacology of spinally-projecting sympathetic pre-autonomic neurones in the paraventricular nucleus of the hypothalamus.

Authors:  Nicolas Nunn; Matthew Womack; Caroline Dart; Richard Barrett-Jolley
Journal:  Curr Neuropharmacol       Date:  2011-06       Impact factor: 7.363

Review 5.  G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei--serpentine gateways to neuroendocrine homeostasis.

Authors:  Georgina G J Hazell; Charles C Hindmarch; George R Pope; James A Roper; Stafford L Lightman; David Murphy; Anne-Marie O'Carroll; Stephen J Lolait
Journal:  Front Neuroendocrinol       Date:  2011-07-23       Impact factor: 8.606

6.  Hypogonadotropic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin B receptor.

Authors:  Tulay Guran; Gwen Tolhurst; Abdullah Bereket; Nuno Rocha; Keith Porter; Serap Turan; Fiona M Gribble; L Damla Kotan; Teoman Akcay; Zeynep Atay; Husniye Canan; Ayse Serin; Stephen O'Rahilly; Frank Reimann; Robert K Semple; A Kemal Topaloglu
Journal:  J Clin Endocrinol Metab       Date:  2009-09-15       Impact factor: 5.958

7.  Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand, [18F]Lu AF10628.

Authors:  Katarina Varnäs; Sjoerd J Finnema; Vladimir Stepanov; Akihiro Takano; Miklós Tóth; Marie Svedberg; Søren Møller Nielsen; Nikolay A Khanzhin; Karsten Juhl; Benny Bang-Andersen; Christer Halldin; Lars Farde
Journal:  Int J Neuropsychopharmacol       Date:  2016-08-12       Impact factor: 5.176
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.