| Literature DB >> 11042610 |
N Ni1, M M El-Sayed, T Sanghvi, S H Yalkowsky.
Abstract
The Setschenow constant, K(salt), of a nonelectrolyte in a NaCl solution is shown to be related to the logarithm of its octanol-water partition coefficient, log K(ow), determined by K(salt) = A log K(ow) + B, where K(ow) is the octanol-water partition coefficient of the solute and the coefficients A and B are constants. The values of A and B were empirically determined from literature data for 62 organic compounds and validated for a test set of 15 compounds including several drugs. Copyright 2000 Wiley-Liss, Inc.Entities:
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Year: 2000 PMID： 11042610 DOI： 10.1002/1520-6017(200012)89:12<1620::aid-jps13>3.0.co;2-n
Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534