Literature DB >> 11042318

Does full-term pregnancy at a young age protect women against breast cancer through hCG?

C V Rao1.   

Abstract

Recent studies found that human and animal breast tissues and human breast cell lines contain low levels of receptors that bind hCG and its structural and functional homologue, LH. Those gonadotropins exert numerous anticancer effects in breast cancer models and cells, which might explain decreased breast cancer incidence in women who complete full-term pregnancies at a young age. The new findings also imply that premature chronic elevations of LH levels might contribute to decreased breast cancer incidence in women with early menopause, and elevated LH levels might contribute to a better prognosis after ovariectomy. Those findings predict that breast cancer risk might be reduced by early hCG treatment of women who plan to delay their first pregnancies; prophylactic hCG treatment might help women with family histories of breast cancer or oncogene mutations that predict breast cancer; and better prognoses might result when hCG is administered to breast cancer tissue.

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Year:  2000        PMID: 11042318     DOI: 10.1016/s0029-7844(00)00983-2

Source DB:  PubMed          Journal:  Obstet Gynecol        ISSN: 0029-7844            Impact factor:   7.661


  2 in total

1.  LH receptor gene expression is essentially absent in breast tumor tissue: implications for treatment.

Authors:  T Martijn Kuijper; Kirsten Ruigrok-Ritstier; Miriam Verhoef-Post; Djura Piersma; Martijn W P Bruysters; Els M J J Berns; Axel P N Themmen
Journal:  Mol Cell Endocrinol       Date:  2009-01-20       Impact factor: 4.102

2.  Hyperemesis gravidarum and subsequent breast cancer risk.

Authors:  G Erlandsson; M Lambe; S Cnattingius; A Ekbom
Journal:  Br J Cancer       Date:  2002-10-21       Impact factor: 7.640

  2 in total

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