| Literature DB >> 11041836 |
P Beak1, D R Anderson, M D Curtis, J M Laumer, D J Pippel, G A Weisenburger.
Abstract
A theoretical foundation, tools for recognition and control, and recent examples of a class of asymmetric transformation termed dynamic thermodynamic resolution are presented. Enantioselective reaction pathways that involve an induced diastereomeric equilibration to intermediates, which are configurationally stable on the time scale of a subsequent reaction, are illustrated. Dynamic thermodynamic resolution differs from the classic, well-documented pathways of kinetic resolution and dynamic kinetic resolution in that equilibration and resolution can be operative on one system in separate controllable steps. This approach offers a high level of flexibility and provides multiple opportunities for optimization of enantioselectivity.Mesh：
Year: 2000 PMID： 11041836 DOI： 10.1021/ar000077s
Source DB: PubMed Journal: Acc Chem Res ISSN： 0001-4842 Impact factor: 22.384