Literature DB >> 110417

Effect of 1-alpha-hydroxyvitamin D3 on osteoporosis in rats induced by oophorectomy.

J U Lindgren, T S Lindholm.   

Abstract

Fifty adult female rats were used to study the effect of 1-alpha-hydroxyvitamin D3 (1alpha-OH-D3) on bone after oophorectomy. The experimental period was 6 months. At the end of the experiment the femurs and the tibias were investigated for bone mass and composition. Significant signs of osteopenia occurred as a result of oophorectomy. The treatment with 1alpha-OH-D3 induced only minor changes in blood chemistry but increased bone mass significantly. The findings support the view that 1alpha-OH-D3 may be a valuable tool in the treatment of osteoporosis resulting from ovarian insufficiency.

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Year:  1979        PMID： 110417     DOI： 10.1007/bf02441179

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  10 in total

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Authors:  O Ahilgren; S E Larsson
Journal:  Acta Pathol Microbiol Scand A       Date:  1975-01

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Authors:  E BARNETT; B E NORDIN
Journal:  Clin Radiol       Date:  1960-07       Impact factor: 2.350

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Authors:  S R ELLIOTT; R A ROBINSON
Journal:  J Bone Joint Surg Am       Date:  1957-01       Impact factor: 5.284

Review 4.  Vitamin D metabolism.

Authors:  H F Deluca
Journal:  Clin Endocrinol (Oxf)       Date:  1977-12       Impact factor: 3.478

5.  Estrogens and postmenopausal osteoporosis.

Authors:  R P Heaney
Journal:  Clin Obstet Gynecol       Date:  1976-12       Impact factor: 2.190

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Authors:  J J Reynolds; M F Holick; H F DeLuca
Journal:  Calcif Tissue Res       Date:  1974

7.  Osteoporosis after oophorectomy in the mature female rat and the effect of oestrogen and-or progestogen replacement therapy in its prevention.

Authors:  J M Aitken; E Armstrong; J B Anderson
Journal:  J Endocrinol       Date:  1972-10       Impact factor: 4.286

8.  On the calcium metabolism and growth rate of rats.

Authors:  H Bohr
Journal:  Calcif Tissue Res       Date:  1968

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Authors:  P D Saville
Journal:  J Am Geriatr Soc       Date:  1969-02       Impact factor: 5.562

10.  Treatment of patients with senile, post-menopausal and corticosteroid-induced osteoporosis with 1alpha-hydroxyvitamin D3 and calcium: short- and long-term effects.

Authors:  T S Lindholm; J A Sevastikoglou; U Lindgren
Journal:  Clin Endocrinol (Oxf)       Date:  1977-12       Impact factor: 3.478
  10 in total
  21 in total

1.  Nondestructive measurement of bone mineral in femurs from ovariectomized rats.

Authors:  D B Kimmel; T J Wronski
Journal:  Calcif Tissue Int       Date:  1990-02       Impact factor: 4.333

2.  Ovariectomy in the rat induces a rapid increase in the urinary excretion of hydroxylysine glycosides and non-reducible crosslink residues.

Authors:  E Casari; M Alfano; M Valente; G D Clarke; G Ferni; B Grazioli
Journal:  Osteoporos Int       Date:  1997       Impact factor: 4.507

3.  Differences of bone mass and bone structure in osteopenic rat models caused by spinal cord injury and ovariectomy.

Authors:  S-D Jiang; C Shen; L-S Jiang; L-Y Dai
Journal:  Osteoporos Int       Date:  2007-01-11       Impact factor: 4.507

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Authors:  V C Jordan; E Phelps; J U Lindgren
Journal:  Breast Cancer Res Treat       Date:  1987-10       Impact factor: 4.872

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Authors:  T V Sanchez; R C Myers; J T Bond; G H Mayor
Journal:  Calcif Tissue Int       Date:  1981       Impact factor: 4.333

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Authors:  P T Beall; L K Misra; R L Young; H J Spjut; H J Evans; A LeBlanc
Journal:  Calcif Tissue Int       Date:  1984-01       Impact factor: 4.333

7.  Bone deficit in ovariectomized rats. Functional contribution of the marrow stromal cell population and the effect of oral dihydrotachysterol treatment.

Authors:  C Tabuchi; D J Simmons; A Fausto; J E Russell; I Binderman; L V Avioli
Journal:  J Clin Invest       Date:  1986-09       Impact factor: 14.808

8.  Cancellous bone resorption in the proximal ilium of the ovariectomized rat.

Authors:  H Devlin; M W Ferguson; D H Carter
Journal:  Calcif Tissue Int       Date:  1990-06       Impact factor: 4.333

9.  Cadmium accelerates bone loss in ovariectomized mice and fetal rat limb bones in culture.

Authors:  M H Bhattacharyya; B D Whelton; P H Stern; D P Peterson
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

10.  Immobilization osteoporosis and active vitamin D: effect of active vitamin D analogs on the development of immobilization osteoporosis in rats.

Authors:  Y Izawa; T Makita; S Hino; Y Hashimoto; K Kushida; T Inoue; H Orimo
Journal:  Calcif Tissue Int       Date:  1981       Impact factor: 4.333
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