Literature DB >> 11038233

In vitro genotoxicity testing of ARASCO and DHASCO oils.

L M Arterburn1, K D Boswell, T Lawlor, M A Cifone, H Murli, D J Kyle.   

Abstract

ARASCO and DHASCO oils are microbially-derived triglycerides rich in arachidonic (20:4n-6) and docosahexaenoic (22:6n-3) acids, respectively. Both oils were tested for mutagenic activity in three different in vitro mutagenesis assays. All assays were conducted with and without metabolic activation. Neither ARASCO nor DHASCO oil was mutagenic in the Ames reverse mutation assay using five different Salmonella histidine auxotroph tester strains, nor were the oils mutagenic in the mouse lymphoma TK(+/-) forward mutation assay. The oils showed no clastogenic activity in chromosomal aberration assays performed with Chinese hamster ovary cells. Based on these assays, neither ARASCO nor DHASCO oils appear to have any genotoxic potential.

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Year:  2000        PMID： 11038233     DOI： 10.1016/s0278-6915(00)00085-5

Source DB:  PubMed          Journal:  Food Chem Toxicol        ISSN： 0278-6915            Impact factor:   6.023


  6 in total

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Review 5.  Preparation of Human Milk Fat Substitutes: A Review.

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  6 in total

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