Literature DB >> 11036161

Noncompetitive inhibition of the glycine receptor-mediated current by melatonin in cultured neurons.

F S Wu1, Y C Yang, J J Tsai.   

Abstract

The effect of melatonin on the glycine receptor-mediated response was studied in cultured chick spinal cord neurons using the whole-cell voltage-clamp recording technique. Melatonin rapidly and reversibly inhibited the glycine-induced current in a dose-dependent fashion, with an EC(50) of 934 microM and a maximal inhibition of 100%. Furthermore, melatonin noncompetitively inhibited the glycine response by an agonist-independent mechanism that was distinct from that of an open-channel blocker.

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Year:  2000        PMID： 11036161     DOI： 10.1016/s0006-8993(00)02804-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  3 in total

1.  After-effects of consecutive sessions of transcranial direct current stimulation (tDCS) in a rat model of chronic inflammation.

Authors:  Gabriela Laste; Wolnei Caumo; Lauren Naomi Spezia Adachi; Joanna Ripoll Rozisky; Isabel Cristina de Macedo; Paulo Ricardo Marques Filho; Wania Aparecida Partata; Felipe Fregni; Iraci L S Torres
Journal:  Exp Brain Res       Date:  2012-07-03       Impact factor: 1.972

2.  Melatonin Suppresses the Kainate Receptor-Mediated Excitation on Gonadotropin-Releasing Hormone Neurons in Female and Male Prepubertal Mice.

Authors:  Santosh Rijal; Dong Hyu Cho; Seon-Ah Park; Seon Hui Jang; István M Ábrahám; Seong Kyu Han
Journal:  Int J Mol Sci       Date:  2020-08-20       Impact factor: 5.923

3.  Melatonin administration reduces inflammatory pain in rats.

Authors:  Gabriela Laste; Isabel Cristina de Macedo; Joanna Ripoll Rozisky; Fernanda Ribeiro da Silva; Wolnei Caumo; Iraci Ls Torres
Journal:  J Pain Res       Date:  2012-09-18       Impact factor: 3.133
  3 in total

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