Literature DB >> 11034309

Observation of DNA-polymer condensate formation in real time at a molecular level.

A L Martin1, M C Davies, B J Rackstraw, C J Roberts, S Stolnik, S J Tendler, P M Williams.   

Abstract

Dynamic real time assembly of toroidal and rod-like DNA condensates has been visualised using atomic force microscopy. Imaging has been conducted in an aqueous environment allowing the visualisation of hydrated, pegylated-polymer DNA condensates undergoing dynamic structural movement and conformational change. A major hurdle in the field of gene delivery is cellular transfection and the subsequent transfer of condensed genetic material to the cell nucleus. An increased understanding of the process of DNA condensation will aid the development and optimisation of gene delivery vectors.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 11034309     DOI： 10.1016/s0014-5793(00)01894-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  The role of a microscopic colloidally stabilized phase in solubilizing oligoamine-condensed DNA complexes.

Authors:  Vladimir S Trubetskoy; Jon A Wolff; Vladimir G Budker
Journal:  Biophys J       Date:  2003-02       Impact factor: 4.033

2.  Direct real-time molecular scale visualisation of the degradation of condensed DNA complexes exposed to DNase I.

Authors:  Hosam G Abdelhady; Stephanie Allen; Martyn C Davies; Clive J Roberts; Saul J B Tendler; Philip M Williams
Journal:  Nucleic Acids Res       Date:  2003-07-15       Impact factor: 16.971

3.  Exploring the interaction of ruthenium(II) polypyridyl complexes with DNA using single-molecule techniques.

Authors:  Aleksandra Mihailovic; Ioana Vladescu; Micah McCauley; Elaine Ly; Mark C Williams; Eileen M Spain; Megan E Nuñez
Journal:  Langmuir       Date:  2006-05-09       Impact factor: 3.882

4.  Tuning DNA Condensation with Zwitterionic Polyamidoamine (zPAMAM) Dendrimers.

Authors:  Min An; Gulen Yesilbag Tonga; Sean R Parkin; Vincent M Rotello; Jason E DeRouchey
Journal:  Macromolecules       Date:  2017-10-09       Impact factor: 5.985

5.  Peptide-functionalized poly(ethylene glycol) star polymers: DNA delivery vehicles with multivalent molecular architecture.

Authors:  Katye M Fichter; Le Zhang; Kristi L Kiick; Theresa M Reineke
Journal:  Bioconjug Chem       Date:  2007-10-04       Impact factor: 4.774

6.  Effects of the incorporation of a hydrophobic middle block into a PEG-polycation diblock copolymer on the physicochemical and cell interaction properties of the polymer-DNA complexes.

Authors:  Rahul Sharma; Jae-Sung Lee; Ryan C Bettencourt; Chuan Xiao; Stephen F Konieczny; You-Yeon Won
Journal:  Biomacromolecules       Date:  2008-10-23       Impact factor: 6.988

7.  DNA release dynamics from reducible polyplexes by atomic force microscopy.

Authors:  Lei Wan; Devika S Manickam; David Oupický; Guangzhao Mao
Journal:  Langmuir       Date:  2008-10-08       Impact factor: 3.882

8.  DNA release dynamics from bioreducible poly(amido amine) polyplexes.

Authors:  Lei Wan; Yezi You; Yi Zou; David Oupický; Guangzhao Mao
Journal:  J Phys Chem B       Date:  2009-10-22       Impact factor: 2.991

Review 9.  Novel imaging technologies for characterization of microbial extracellular polysaccharides.

Authors:  Magnus B Lilledahl; Bjørn T Stokke
Journal:  Front Microbiol       Date:  2015-05-28       Impact factor: 5.640

10.  Direct monitoring of the stepwise condensation of kinetoplast DNA networks.

Authors:  Nurit Yaffe; Dvir Rotem; Awakash Soni; Danny Porath; Joseph Shlomai
Journal:  Sci Rep       Date:  2021-01-15       Impact factor: 4.379
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.