| Literature DB >> 11033095 |
F I Tarazi1, K Zhang, R J Baldessarini.
Abstract
Changes in ionotropic glutamate NMDA, AMPA and KA receptor binding in rat caudate-putamen were examined by quantitative in vitro receptor autoradiography 5 weeks after lesioning nigrostriatal dopaminergic projections. In this animal model of Parkinson's disease, density of binding in caudate-putamen increased at KA, but not NMDA or AMPA receptors. The findings indicate that nigrostriatal dopamine denervation can selectively enhance KA receptor levels in rat basal ganglia, suggest that KA receptors contribute to the pathophysiology of Parkinson's disease, and may suggest innovative treatments.Entities:
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Year: 2000 PMID： 11033095 DOI： 10.1016/s0006-8993(00)02812-2
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252