Literature DB >> 11032556

Biochemistry. Ubiquitination--more than two to tango.

C A Joazeiro1, T Hunter.   

Abstract

The ubiquitin pathway in the cell is an elegant system for targeting unwanted proteins for degradation. Three enzymes, E1, E2, and E3, are responsible for attaching the ubiquitin tag to proteins destined to be chopped up. In their Perspective, Joazeiro and Hunter discuss new structural findings that reveal the part played by an E3 called c-Cbl in this ubiquitinating process.

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Year:  2000        PMID： 11032556     DOI： 10.1126/science.289.5487.2061

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  16 in total

1.  Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.

Authors:  Marcie Colledge; Eric M Snyder; Robert A Crozier; Jacquelyn A Soderling; Yetao Jin; Lorene K Langeberg; Hua Lu; Mark F Bear; John D Scott
Journal:  Neuron       Date:  2003-10-30       Impact factor: 17.173

2.  Simulations of the confinement of ubiquitin in self-assembled reverse micelles.

Authors:  Jianhui Tian; Angel E García
Journal:  J Chem Phys       Date:  2011-06-14       Impact factor: 3.488

3.  Glucocorticoid regulates TrkB protein levels via c-Cbl dependent ubiquitination: a decrease in c-Cbl mRNA in the prefrontal cortex of suicide subjects.

Authors:  Chirayu Pandya; Ammar Kutiyanawalla; Gustavo Turecki; Anilkumar Pillai
Journal:  Psychoneuroendocrinology       Date:  2014-04-06       Impact factor: 4.905

4.  Cell biology: Ubiquitination without E1 and E2 enzymes.

Authors:  Sagar Bhogaraju; Ivan Dikic
Journal:  Nature       Date:  2016-04-20       Impact factor: 49.962

5.  Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.

Authors:  Y T Kwon; Z Xia; I V Davydov; S H Lecker; A Varshavsky
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

6.  Ischemic postconditioning protects cardiomyocytes against ischemia/reperfusion injury by inducing MIP2.

Authors:  Hong-Lin Zhu; Xing Wei; Shun-Lin Qu; Chi Zhang; Xiao-Xia Zuo; Yan-Sheng Feng; Qi Luo; Guang-Wen Chen; Mei-Dong Liu; Lei Jiang; Xian-Zhong Xiao; Kang-Kai Wang
Journal:  Exp Mol Med       Date:  2011-08-31       Impact factor: 8.718

7.  Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.

Authors:  Noel A Warfel; Matt Niederst; Michael W Stevens; Paul M Brennan; Margaret C Frame; Alexandra C Newton
Journal:  J Biol Chem       Date:  2011-03-28       Impact factor: 5.157

8.  Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation.

Authors:  Liling Yang; Shuxing Wang; Backil Sung; Grewo Lim; Jianren Mao
Journal:  J Biol Chem       Date:  2008-06-06       Impact factor: 5.157

9.  Expression of Cbl linking with the epidermal growth factor receptor system is associated with tumor progression and poor prognosis of human gastric carcinoma.

Authors:  Reiko Ito; Hirofumi Nakayama; Kazuhiro Yoshida; Shunji Matsumura; Noriko Oda; Wataru Yasui
Journal:  Virchows Arch       Date:  2004-02-26       Impact factor: 4.064

10.  A system-based comparison of gene expression reveals alterations in oxidative stress, disruption of ubiquitin-proteasome system and altered cell cycle regulation after exposure to cadmium and methylmercury in mouse embryonic fibroblast.

Authors:  Xiaozhong Yu; Joshua F Robinson; Jaspreet S Sidhu; Sungwoo Hong; Elaine M Faustman
Journal:  Toxicol Sci       Date:  2010-01-08       Impact factor: 4.849
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