BACKGROUND: Parathyroid hormone-related protein (PTHrP) is produced by various neoplasms and is known to be a causative factor of hypercalcemia of malignancy. It has also been suggested to act as a cytokine for tumor progression. The purpose of this study was to clarify the significance of PTHrP expression in breast carcinoma. METHODS: PTHrP expression was examined in 177 surgically resected breast carcinoma specimens by immunohistochemistry using a monoclonal antibody against the for PTHrP, The relationship of PTHrP expression with clinicopathological factors was analyzed and the clinical courses of the patients are reported. RESULTS: Positive PTHrP staining was detected in 113 ( 64%) of the breast tumors. Among the positive cases, 36 (32%) of the tumors clearly showed strong expression. When the PTHrP expression was divided into three categories, a significant positive relationship was found between PTHrP expression and histological grade of tumor. PTHrP expression was also significantly related to bone metastasis but the staining degree of PTHrP was not. The patients with positive PTHrP tended to have poor outcome in proportion to the staining degree. Univariate analysis demonstrated a significantly shorter overall survival for patients expressing PTHrP, and in multivariate analysis showed that PTHrP status and nodal status were associated with a significantly shorter overall survival. CONCLUSION: Our results suggest that PTHrP expression is not only correlated with bone metastasis but is also related to the progression of breast carcinoma, and that overexpression of PTHrP may be a potential prognostic factor for human breast carcinoma.
BACKGROUND:Parathyroid hormone-related protein (PTHrP) is produced by various neoplasms and is known to be a causative factor of hypercalcemia of malignancy. It has also been suggested to act as a cytokine for tumor progression. The purpose of this study was to clarify the significance of PTHrP expression in breast carcinoma. METHODS:PTHrP expression was examined in 177 surgically resected breast carcinoma specimens by immunohistochemistry using a monoclonal antibody against the for PTHrP, The relationship of PTHrP expression with clinicopathological factors was analyzed and the clinical courses of the patients are reported. RESULTS: Positive PTHrP staining was detected in 113 ( 64%) of the breast tumors. Among the positive cases, 36 (32%) of the tumors clearly showed strong expression. When the PTHrP expression was divided into three categories, a significant positive relationship was found between PTHrP expression and histological grade of tumor. PTHrP expression was also significantly related to bone metastasis but the staining degree of PTHrP was not. The patients with positive PTHrP tended to have poor outcome in proportion to the staining degree. Univariate analysis demonstrated a significantly shorter overall survival for patients expressing PTHrP, and in multivariate analysis showed that PTHrP status and nodal status were associated with a significantly shorter overall survival. CONCLUSION: Our results suggest that PTHrP expression is not only correlated with bone metastasis but is also related to the progression of breast carcinoma, and that overexpression of PTHrP may be a potential prognostic factor for humanbreast carcinoma.
Authors: Paweł Surowiak; Piotr Dziegiel; Rafał Matkowski; Mirosław Sopel; Andrzej Wojnar; Jan Kornafel; Maciej Zabel Journal: Virchows Arch Date: 2003-01-25 Impact factor: 4.064
Authors: Maya Ghoussaini; Olivia Fletcher; Kyriaki Michailidou; Clare Turnbull; Marjanka K Schmidt; Ed Dicks; Joe Dennis; Qin Wang; Manjeet K Humphreys; Craig Luccarini; Caroline Baynes; Don Conroy; Melanie Maranian; Shahana Ahmed; Kristy Driver; Nichola Johnson; Nicholas Orr; Isabel dos Santos Silva; Quinten Waisfisz; Hanne Meijers-Heijboer; Andre G Uitterlinden; Fernando Rivadeneira; Per Hall; Kamila Czene; Astrid Irwanto; Jianjun Liu; Heli Nevanlinna; Kristiina Aittomäki; Carl Blomqvist; Alfons Meindl; Rita K Schmutzler; Bertram Müller-Myhsok; Peter Lichtner; Jenny Chang-Claude; Rebecca Hein; Stefan Nickels; Dieter Flesch-Janys; Helen Tsimiklis; Enes Makalic; Daniel Schmidt; Minh Bui; John L Hopper; Carmel Apicella; Daniel J Park; Melissa Southey; David J Hunter; Stephen J Chanock; Annegien Broeks; Senno Verhoef; Frans B L Hogervorst; Peter A Fasching; Michael P Lux; Matthias W Beckmann; Arif B Ekici; Elinor Sawyer; Ian Tomlinson; Michael Kerin; Frederik Marme; Andreas Schneeweiss; Christof Sohn; Barbara Burwinkel; Pascal Guénel; Thérèse Truong; Emilie Cordina-Duverger; Florence Menegaux; Stig E Bojesen; Børge G Nordestgaard; Sune F Nielsen; Henrik Flyger; Roger L Milne; M Rosario Alonso; Anna González-Neira; Javier Benítez; Hoda Anton-Culver; Argyrios Ziogas; Leslie Bernstein; Christina Clarke Dur; Hermann Brenner; Heiko Müller; Volker Arndt; Christa Stegmaier; Christina Justenhoven; Hiltrud Brauch; Thomas Brüning; Shan Wang-Gohrke; Ursula Eilber; Thilo Dörk; Peter Schürmann; Michael Bremer; Peter Hillemanns; Natalia V Bogdanova; Natalia N Antonenkova; Yuri I Rogov; Johann H Karstens; Marina Bermisheva; Darya Prokofieva; Elza Khusnutdinova; Annika Lindblom; Sara Margolin; Arto Mannermaa; Vesa Kataja; Veli-Matti Kosma; Jaana M Hartikainen; Diether Lambrechts; Betul T Yesilyurt; Giuseppe Floris; Karin Leunen; Siranoush Manoukian; Bernardo Bonanni; Stefano Fortuzzi; Paolo Peterlongo; Fergus J Couch; Xianshu Wang; Kristen Stevens; Adam Lee; Graham G Giles; Laura Baglietto; Gianluca Severi; Catriona McLean; Grethe Grenaker Alnaes; Vessela Kristensen; Anne-Lise Børrensen-Dale; Esther M John; Alexander Miron; Robert Winqvist; Katri Pylkäs; Arja Jukkola-Vuorinen; Saila Kauppila; Irene L Andrulis; Gord Glendon; Anna Marie Mulligan; Peter Devilee; Christie J van Asperen; Rob A E M Tollenaar; Caroline Seynaeve; Jonine D Figueroa; Montserrat Garcia-Closas; Louise Brinton; Jolanta Lissowska; Maartje J Hooning; Antoinette Hollestelle; Rogier A Oldenburg; Ans M W van den Ouweland; Angela Cox; Malcolm W R Reed; Mitul Shah; Ania Jakubowska; Jan Lubinski; Katarzyna Jaworska; Katarzyna Durda; Michael Jones; Minouk Schoemaker; Alan Ashworth; Anthony Swerdlow; Jonathan Beesley; Xiaoqing Chen; Kenneth R Muir; Artitaya Lophatananon; Suthee Rattanamongkongul; Arkom Chaiwerawattana; Daehee Kang; Keun-Young Yoo; Dong-Young Noh; Chen-Yang Shen; Jyh-Cherng Yu; Pei-Ei Wu; Chia-Ni Hsiung; Annie Perkins; Ruth Swann; Louiza Velentzis; Diana M Eccles; Will J Tapper; Susan M Gerty; Nikki J Graham; Bruce A J Ponder; Georgia Chenevix-Trench; Paul D P Pharoah; Mark Lathrop; Alison M Dunning; Nazneen Rahman; Julian Peto; Douglas F Easton Journal: Nat Genet Date: 2012-01-22 Impact factor: 38.330
Authors: Cameron N Johnstone; Yvonne E Smith; Yuan Cao; Allan D Burrows; Ryan S N Cross; Xiawei Ling; Richard P Redvers; Judy P Doherty; Bedrich L Eckhardt; Anthony L Natoli; Christina M Restall; Erin Lucas; Helen B Pearson; Siddhartha Deb; Kara L Britt; Alexandra Rizzitelli; Jason Li; Judith H Harmey; Normand Pouliot; Robin L Anderson Journal: Dis Model Mech Date: 2015-01-29 Impact factor: 5.758